Table II.
Changes to the body weight (g) in the HFD-induced hyperlipemic hamster model.
| Polycan groups (mg/kg) | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| Time point | Sham | Control | SIMVA | 31.25 | 62.5 | 125 |
| Day -1 | 97.62±12.08 | 95.44±4.43 | 96.40±8.75 | 95.82±2.06 | 95.32±8.73 | 96.66±12.72 |
| Day 0a | 93.48±12.33 | 92.20±4.19 | 91.36±8.24 | 92.30±2.92 | 90.24±8.33 | 87.68±17.28 |
| Day 1 | 96.00±13.34 | 90.54±4.34 | 90.46±8.20 | 90.34±2.30 | 86.98±7.25 | 89.60±14.36 |
| Day 7 | 100.86±14.69 | 90.24±12.58 | 95.66±8.21 | 92.00±5.19 | 84.22±10.08 | 94.86±15.28 |
| Day 14 | 103.76±7.64 | 94.90±12.09 | 95.24±5.45 | 96.24±7.90 | 91.62±11.15 | 100.32±15.93 |
| Day 21 | 107.10±8.00 | 100.26±13.92 | 101.86±6.87 | 101.60±11.55 | 96.64±18.65 | 105.02±16.48 |
| Day 28 | 118.30±9.63 | 110.92±14.70 | 103.08±11.45d | 110.24±16.12 | 106.78±15.91 | 112.44±15.78 |
| Day 35 | 123.34±9.10 | 116.28±13.41 | 106.02±15.58d | 119.46±19.53 | 112.88±17.21 | 124.18±9.85 |
| Day 42 | 131.58±7.41 | 133.64±14.08 | 117.96±16.38 | 130.76±13.34 | 126.84±9.26 | 129.98±8.82 |
| Day 49 | 133.00±6.94 | 145.06±9.66d | 129.64±20.84 | 139.74±20.31 | 144.90±13.18 | 138.48±7.75 |
| Day 55 | 134.30±7.56 | 158.42±12.57d | 126.38±25.79 | 148.10±21.14 | 152.16±19.10 | 149.56±16.77 |
| Day 56b | 126.70±6.87 | 147.58±10.93d | 116.80±24.84 | 136.70±16.41 | 140.38±17.49 | 138.14±15.70 |
| Gainc | 33.22±10.97 | 55.38±8.95d | 25.44±18.38e | 44.40±14.60 | 50.14±15.42 | 50.46±27.13 |
Results are expressed as the mean ± standard deviation (n=5).
a
Initial dose of the test article and HFD supply after overnight fasting;
b
At sacrifice after overnight fasting;
c
Body weight gain (g) = body weight gain throughout the whole experimental period (day 0 - day 56).
d
P<0.05, vs. sham (MW test);
e
P<0.05, vs. vehicle control (MW test).
SIMVA, simvastatin; HFD, high-fat diet; MW, Mann-Whitney-Wilcoxon.