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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: JAMA Psychiatry. 2015 Feb 1;72(2):143–151. doi: 10.1001/jamapsychiatry.2014.2133

Table 3. Final PRIMROSE models coefficients, after backwards eliminations.

PRIMROSE Lipid model PRIMROSE BMI model
β Coefficient HR 95% CI p β Coefficient HR 95% CI p
Gender (female v male) −0.1795 0.84 0.72 to 0.96 0.02 −0.49376 0.61 0.53 to 0.7 <0.001
Age, years (per log year increase) 3.78124 43.87 34.61 to 55.61 <0.001 3.50943 33.43 26.91 to 41.52 <0.001
SBP if no baseline anti-hypertensive use, mmHg (per 10 unit increase) 0.07651 1.08 1.04 to 1.12 <0.001 0.0893 1.09 1.05 to 1.14 <0.001
SBP if baseline anti-hypertensive use, mmHg (per 10 unit increase) −0.00316 1 0.95 to 1.05 0.9 0.0005 1 0.95 to 1.05 >0.9
Total cholesterol, mmol/L (per unit increase) 0.11763 1.12 1.03 to 1.22 0.009
HDL cholesterol, mmol/L (per unit increase) −0.8183 0.44 0.24 to 0.8 0.01
Weight, kg (per 10 unit increase) 0.0068 1.01 0.97 to 1.05 0.7
Height, cm (per 10 unit increase) −0.12413 0.88 0.81 to 0.96 0.004
History of Diabetes (yes v no) 0.37734 1.46 1.2 to 1.77 <0.001 0.44971 1.57 1.33 to 1.85 <0.001
Predominant smoking history <0.001 <0.001
Never 0 1 0 1
Ex 0.01639 1.02 0.9 to 1.15 0.0738 1.08 0.96 to 1.21
Current 0.29659 1.35 1.2 to 1.51 0.38081 1.46 1.32 to 1.62
Calendar year at baseline (per 1 year increase) −0.07043 0.93 0.92 to 0.95 <0.001 −0.07524 0.93 0.91 to 0.94 <0.001
Use of anti-depressants at baseline (yes v no) 0.2104 1.23 1.12 to 1.36 <0.001 0.21846 1.24 1.13 to 1.37 <0.001
History of heavy drinking (yes v no) 0.41392 1.51 1.25 to 1.83 <0.001 0.30721 1.36 1.15 to 1.61 <0.001
Townsend quintile of deprivation 0.06 0.01
1 (= least deprived) 0 1 0 1
2 0.10963 1.12 0.96 to 1.29 0.10919 1.12 0.97 to 1.28
3 0.16388 1.18 1.03 to 1.35 0.18412 1.2 1.06 to 1.37
4 0.1828 1.2 1.03 to 1.4 0.20238 1.22 1.06 to 1.41
5 (= most deprived) 0.22126 1.25 1.06 to 1.46 0.24762 1.28 1.1 to 1.49
Severe mental illness diagnosis 0.001 0.002
Schizophrenia 0 1 0 1
Bipolar disorder 0.11177 1.12 0.99 to 1.26 0.0978 1.1 0.98 to 1.24
Other psychosis 0.21004 1.23 1.1 to 1.39 0.19063 1.21 1.08 to 1.35
Unknown - on severe mental illness register 0.01526 1.02 0.86 to 1.19 −0.01138 0.99 0.85 to 1.15
Use of second generation antipsychotics at baseline (yes v no) 0.12121 1.13 0.96 to 1.32 0.1 0.17662 1.19 1.02 to 1.4 0.03
Use of first generation antipsychotics at baseline (yes v no) 0.1205 1.13 1.02 to 1.25 0.02
So(10) 0.968011 0.951285

S0(10) is the predicted baseline survival at ten years for the model