Table 5.
Effects of NPY on n production of immune cells
| Cells | Sp | Specification | Rec | Effect | Age | Signal | Ref |
|---|---|---|---|---|---|---|---|
| Macrophages | M | Peritoneal resident cells (macrophages+lymphocytes) | ↓ TNF-α (LPS-stimulated) | (De la Fuente et al. 2001a) | |||
| Macrophages | M | Peritoneal resident cells (macrophages+lymphocytes) | ↑ IL-1β (Con A-stimulated) | adult | (De la Fuente et al. 2001a) | ||
| Macrophages | M | Peritoneal resident cells (macrophages+lymphocytes) | ↓IL-1β (Con A-stimulated) | old | (De la Fuente et al. 2001a) | ||
| Macrophages | M | Peritoneal, thioglycollate-elicited | Y1 | ↓ MCP-1 + TNF (LPS- stimulated) | (Macia et al. 2012b) | ||
| Monocytes / Macrophages | M | RAW 264.7 cell line | Y1 | ↑ TGF-β1 | PI3K | (Zhou et al. 2008a) | |
| Macrophages | M | Spleen tissue slice | Y1 | ↓ IL-6 (spontaneous, α2 adrenoceptor agonist) | (Straub et al. 2000b) | ||
| Macrophages | M | Spleen tissue slice | Y1 | ↑ IL-6 (β adrenoceptor agonist) | (Straub et al. 2000b) | ||
| Macrophages | M | Peritoneal, thioglycollate-elicited | Y1 | ↑ high-mobility group box 1 secretion | young | PKC/ERK | (Zhou et al. 2013) |
| DCs | H | Blood | ↑ IL-6 + IL-10 (Th2 polarization) | (Buttari et al. 2014) | |||
| Leukocytes | M | Peritoneal resident cells (macrophages+lymphocytes) | ↓ IL-2 (Con A-stimulated) | adult | (Puerto et al. 2005) | ||
| Leukocytes | H | Blood | ↑ IL-βp, IL-6, TNF-α | (Hernanz et al. 1996) | |||
| Leukocytes | M | Peritoneal resident cells (macrophages+lymphocytes) | ↓TNF-α (LPS-stimulated) | adult | (Puerto et al. 2005) | ||
| Lymphocytes | M | ↓ IL-2 (Con A-stimulated) | adult | (Medina et al. 2000a) | |||
| T cells | M | Nonadherent splenocytes + T cell clones | ↓ IFN-α + ↑ IL-4 (Th2 polarization) | (Kawamura et al. 1998) | |||
| T cells | M | T cell lines | ↑ IL-2, IFN-γ, IL-4 | (Levite 1998) | |||
| T cells | M | Spleen | Y1 | ↓ IFN-γ (anti-CD3 Ab-stimulated) | (Bedoui et al. 2003) |
Abbreviations: Ab, antibody, Con A, concanavalin A; DCs, dendritic cells; ERK, extracellular signal regulated kinases; H, human; IFN, interferon; IL, interleukin, LPS, lipopolysaccharide; M, mouse; MCP-1, monocyte chemotactic protein-1; PI3K, phosphoinositide 3-kinase; PKC, protein kinase C; Rec, receptor; Sp, species; TGF, transforming growth factor; TNF, tumor necrosis factor.