Table 2.

The effect of salsolinol on dopamine, its metabolites concentration in rats, and the rate of dopamine metabolism in striatum

Treatment	DA	DOPAC	3-MT	HVA	HVA/DA	DOPAC/DA	3-MT/DA
a: Salsolinol—acute
Control	9,042 ± 1,054	1,238 ± 62	438 ± 48	675 ± 113	7.4 ± 0.7	14 ± 2	4.8 ± 0.2
Salsolinol	9,457 ± 1,008	1,584 ± 227**	689 ± 384	897 ± 281	11 ± 3**	16 ± 2*	5.1 ± 0.5
t	−0.70	−3.60	−1.57	−1.82	−6.28	−2.32	−1.02
df	10	12	12	12	12	12	12
P	N.S.	P ≤ 0.01	N.S.	N.S.	P ≤ 0.01	P < 0.05	N.S.
b: Salsolinol—chronic, 2h withdrawal
Control	10,439 ± 815	1467 ± 131	554 ± 58	1,149 ± 83	11 ± 1.3	14 ± 2	5.3 ± 0.5
Salsolinol	11,415 ± 1044	1,789 ± 327*	514 ± 26	1,377 ± 296	12 ± 2.1	16 ± 2	4.5 ± 0.5*
t	−1.95	−2.42	1.65	−1.96	−1.03	−1.52	2.77
df	12	12	12	12	12	12	12
P	N.S.	P < 0.05	N.S.	N.S.	N.S.	N.S.	P < 0.05
c: Salsolinol—chronic, 24h withdrawal
Control	13,843 ± 1,626	1,728 ± 178	665 ± 62	1,263 ± 179	9 ± 2	13 ± 1	4.8 ± 0.3
Salsolinol	13,808 ± 1,222	1,719 ± 312	679 ± 127	1,169 ± 405	8 ± 2	12 ± 1	4.9 ± 0.8
t	0.05	0.06	−0.26	0.56	0.75	0.25	−0.30
df	12	12	12	12	12	12	12
P	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.

Control group received saline. Salsolinol was administrated in a dose 100 mg/kg i.p. once (acute) or for 14 consecutive days (chronic); N = 6–8 animals per group. The concentrations of dopamine and its metabolites were measured in ng/g wet tissue. The data are the mean ± SD. Following Shapiro–Wilk test, for normality, the data were compared using Student’s t test for independent group (control vs. salsolinol 100 mg/kg group). The null hypothesis of the lack of differences between the investigated groups was adopted (P > 0.05). The alternative hypothesis commanded the existence of differences between groups; statistical significance: * P < 0.05, ** P < 0.01