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. 2015 Feb 10;7(2):559–589. doi: 10.3390/v7020559

Figure 3.

Figure 3

Relative effects of pooled classes I and III plasma samples on the barrier function of Vero E6 cell monolayers in assays using thrombin (Arg) and plasmin (TA) inhibitors. (A) Class I and controls (cntrl); (B) Class III and controls (cntrl); (C) Ratiometric plot of Arg/(Arg + TA) versus time, used to determine activity of plasmin in classes I and III samples. The result shows that plasmin expression is significant in class I. Dimethyl sulfoxide (DMSO) was used to solubilize argatroban. The final concentration of DMSO in media was uniformly kept at <1% in all samples; (D) List of false discovery rate (FDR) - adjusted p-values (<0.01) used to determine whether the recovery endpoint (6 h) of cell barrier function in the assay conditions shown in A and B differ significantly from the controls. The assays on the list were found to differ significantly from the controls.