Figure 4.

ECIS analysis of cell monolayers exposed to serial plasma samples. (A) Serial changes of ECIS profiles on different days suggest the diminution of thrombin expression on day five; (B) Relative effect of argatroban on day one and day five samples, implicate thrombin expression in day 1 sample and negligible amount on day five sample, perhaps indicating patient recovery. Dimethyl sulfoxide (DMSO) was used to solubilize argatroban. (C) Ratiometric plot of Arg/(Arg+TA) versus time was used to determine activity of plasmin in class II samples. The results show that plasmin activity is not significant in class II as measured by assay endpoint determinations between controls and class II serial samples.