Figure 1.

The ANK repeat unit from the ankyrinR protein. Example of an ANK motif highlighting the 5^th repeat unit in the ankyrinR structure (PDB ID: 1N11) [52]. β-turns (orange) within the loops (green) link the helix pairs and project outwards in a conserved manner at an angle of approximately 90° from the α-helices (purple) [47,52,56]. This arrangement has been likened to a “cupped hand” where the convex surface forms the “back” (a)’ the concave surface the “palm” (b)’ and the loops form the “fingers” (c). Blue and red indicate the N- and C-termini respectively.