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. 2015 Feb 15;7(2):709–738. doi: 10.3390/v7020709

Figure 2.

Figure 2

The vaccinia virus K1L ankyrin protein structure (PDB ID: 3KEA) [58]. ANK repeats are numbered A1-A9; the terminal ANK repeat motifs 1 and 9 are in-complete motifs in the structure. The blue asterisk refers to residues F82 and S83 on A3 [59] required for in vitro viral replication; the red asterisk refers to residues C47 and N51 on the A2 repeat that are spatially contiguous with F82 and S83 and are also required for host-range function. The arrow indicates a surprising 90° shift in the orientation of β-turn loop arrangement from repeats A4 to A5.