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. 2015 Feb 15;7(2):709–738. doi: 10.3390/v7020709

Figure 3.

Figure 3

Representation of a cellular SCF1 ubiquitin ligase complex following neddylation, where NEDD8 ligation to the Cul1 scaffold facilitates a re-configuration of the Cul1 C-terminus. This enables the flexible re-orientation of the Rbx1 RING domain, together with its bound E2 and an associated ubiquitin allowing the subsequent transfer and ligation of ubiquitin at specific lysine residues in the substrate or previously bound ubiquitins. Poxviral ANK/F-box proteins are known to bind to Skp1, via their PRANC/F-box region, and therefore could replace cellular substrate receptors and interact with possible substrates using their ANK repeats as the substrate interaction domain.