Table 3.
Poxviral ANK/F-box proteins and their described interaction partners. Known interacting proteins include key components of the SCF1 ubiquitin ligase complex (Skp1 and Cul1), with other known protein interactions also shown.
| Genus | Species | Protein | SCF1 Interaction | Other Interaction | Host Range | Ref. | |
|---|---|---|---|---|---|---|---|
| OPXV | ECTV | EVM002 | Skp1 | p105 | [83,116] | ||
| EVM005 | Skp1 | Cul1 | [83,116] | ||||
| EVM154 | Skp1 | [83,116] | |||||
| EVM165 | Skp1 | [116] | |||||
| CPXV | CP77 | Skp1 | Cul1 | p65 | Yes | [79] | |
| Skp1 | HMG20A | [118] | |||||
| CPXV-006 | Skp1 | p105 | [81] | ||||
| VACV | 68k | Skp1 | Cul1 | Yes | [82] | ||
| VARV | G1R | Skp1 | p105 | [81] | |||
| MPXV | MPXV-003 | Skp1 | p105 | [81] | |||
| LPXV | MYXV | M-T5 | Skp1 | Cul1 | Akt | Yes | [85,115] |
| M148R a | Skp1 | [85,119] | |||||
| M149R | Skp1 | [85,119] | |||||
| M150R b | Skp1 | Cul1 | [84,85,95] | ||||
| PPOV | ORFV | OV008 | Skp1 | Cul1 | [78] | ||
| OV123 | Skp1 | Cul1 | [78] | ||||
| OV126 c | Skp1 | Cul1 | [78,120] | ||||
| OV128 | Skp1 | Cul1 | [78] | ||||
| OV129 | Skp1 | Cul1 | CAND1 | [78] | |||
| AVPV | FWPX | FPV014 | Skp1 | [117] | |||
a localises to nucleolus; b localises to nucleus with NF-κB; c localises to mitochondria. PPOV, Parapoxvirus; LPXV, Leporipoxvirus; OPXV, Orthopoxvirus; AVPV, Avipoxvirus. ORFV, orf virus; MYXV, myxoma virus; ECTV, ectromelia virus; CPXV, cowpox virus; VACV, vaccinia virus; VARV, variola virus; MPXV, monkeypox virus; FWPX, fowlpox virus.