. 2014 Nov 27;32(2):297–304. doi: 10.1007/s10815-014-0393-y

Table. 2.

Results of the relationship between the meta-analysis of the ESR1 gene PvuII polymorphism and POF

Comparison	Population	N	Sample Size		Test of association				M	test of heterogeneity
Comparison	Population	N	Case	Control	OR^a	95%CI^b		P_OR	M	x ²	Pvalue ^c	I²(%)
C vs. T	overall	3	956	1836	0.735	0.624	0.865	0.001	F	4.13	0.127	51.6
	asian	2	562	742	0.620	0.491	0.782	0.001	F	0.03	0.871	0.0
	european	1	394	1094	0.870	0.690	1.096	–	–	–	–	–
CC vs. TT	overall	3	246	370	0.540	0.382	0.764	0.001	F	4.21	0.122	52.54
	asian	2	148	190	0.359	0.212	0.610	0.001	F	0.00	0.956	0.0
	european	1	98	280	0.751	0.471	1.198	0.001	–	–	–	–
CT vs. TT	overall	3	364	562	0.735	0.555	0.972	0.031	F	3.30	0.192	39.5
	asian	2	207	249	0.552	0.363	0.893	0.005	F	0.02	0.889	0.0
	european	1	157	413	0.933	0.637	1.367	0.031	–	–	–	–
CT + CC vs. TT	overall	3	478	818	0.618	0.396	0.966	0.035	R	4.67	0.097	57.2
	asian	2	281	371	0.458	0.325	0.722	0.001	F	0.12	0.732	0.0
	european	1	197	547	0.873	0.609	1.251	0.035	–	–	–	–
CCVS.TT + CT	overall	3	478	818	0.659	0.502	0.864	0.003	F	1.51	0.469	0.0
	asian	2	281	371	0.566	0.392	0.819	0.002	F	0.15	0.701	0.0
	european	1	197	547	0.785	0.527	1.169	0.003	–	–	–	–

a, OR odds ratio

b, 95 % confidence interval

c, Pvalue for heterogeneity based on Q test

M model of meta-analysis, F fixed-effects model, R random-effects model