Table 2.
Animal and Eye Data
|
Eye No.* |
Animal ID |
Wt, kg |
Age, y |
Species† |
Sex‡ |
Eye§ |
IOP,‖ mm Hg |
BMO Area, 3D HMRN,¶ mm2 |
No. Section Images# |
3D HMRN Voxel Resolution** |
BD†† Mean ± SD, μm |
PD†† Mean ± SD, μm |
CTVF*†† |
CTV,†† × 106 μm3 |
LV,†† × 106 μm3 |
| 1 | 23510 | 4.9 | 9.5 | R | F | R | 12 | 1.180 | 561 | H | 14.2 ± 1.3 | 35.6 ± 3.4 | 0.247 | 53.34 | 215.42 |
| 2 | AM89‡‡ | 8.9 | 21.9 | R | M | L | 12 | 1.240 | 634 | H | 14.0 ± 1.7 | 29.8 ± 4.9 | 0.331 | 38.07 | 115.47 |
| 3 | 25341 | 5.4 | 1.9 | R | M | R | 13 | 1.199 | 484 | H | 19.1 ± 3.1 | 32.6 ± 2.6 | 0.357 | 56.79 | 159.94 |
| 4 | 26161‡‡ | 3.3 | 1.4 | R | F | L | 8 | 1.057 | 1018 | H | 14.9 ± 1.6 | 26.9 ± 2.5 | 0.359 | 37.09 | 102.30 |
| 5 | AA3G | 8.2 | 8.3 | C | M | L | 11 | 0.885 | 290 | L | 18.7 ± 1.5 | 32.5 ± 3.2 | 0.363 | 64.26 | 178.23 |
| 6 | 7489 | 5.8 | 5.8 | R | M | R | 8 | 1.722 | 240 | L | 18.9 ± 2.2 | 27.8 ± 2.4 | 0.377 | 106.85 | 283.23 |
| 7 | AA4C | 7.5 | 8.3 | C | M | R | 8 | 1.323 | 222 | L | 16.8 ± 3.3 | 26.0 ± 2.9 | 0.380 | 59.44 | 156.91 |
| 8 | 23533 | 3.7 | 8.3 | R | F | R | 8 | 1.048 | 607 | H | 17.8 ± 2.5 | 30.7 ± 3.4 | 0.388 | 62.39 | 160.68 |
| 9 | AA40 | 7.6 | 8.1 | C | M | L | 11 | 1.360 | 237 | L | 18.0 ± 2.1 | 28.6 ± 2.5 | 0.388 | 66.94 | 175.77 |
| 10 | 514 | 6 | 5.2 | R | M | R | 8 | 1.195 | 250 | L | 20.4 ± 4.9 | 27.2 ± 3.4 | 0.402 | 91.67 | 223.79 |
| 11 | 23540 | 5.3 | 9 | R | F | R | 13 | 1.280 | 524 | H | 19.6 ± 2.5 | 29.9 ± 2.8 | 0.405 | 76.25 | 186.94 |
| 12 | 300 | 6.8 | 10.3 | R | M | R | 10 | 1.059 | 183 | L | 18.4 ± 2.5 | 25.2 ± 2.9 | 0.410 | 57.87 | 137.40 |
| 13 | 5644 | 7.8 | 6.2 | R | M | R | 11 | 1.312 | 227 | L | 19.1 ± 1.7 | 26.6 ± 2.7 | 0.411 | 129.77 | 312.13 |
| 14 | AA37 | 8.2 | 8.3 | C | M | R | 10 | 1.296 | 290 | L | 22.5 ± 3.1 | 26.2 ± 3.1 | 0.475 | 100.79 | 212.50 |
| 15 | 25564‡‡ | 3.7 | 2.3 | R | F | L | 11 | 1.138 | 880 | H | 18.8 ± 2.9 | 25.2 ± 3.4 | 0.495 | 56.67 | 115.77 |
| 16 | AA3K | 7.2 | 8.3 | C | M | L | 13 | 1.385 | 320 | L | 23.0 ± 3.7 | 24.0 ± 3.5 | 0.519 | 90.44 | 178.23 |
| 17 | 25357‡‡ | 5.5 | 2.6 | R | M | L | 8 | 1.422 | 771 | H | 21.0 ± 2.8 | 24.2 ± 1.9 | 0.528 | 101.07 | 190.84 |
| 18 | AO23‡‡ | 7.2 | 20 | R | F | L | 9 | 1.138 | 916 | H | 18.3 ± 1.8 | 20.0 ± 3.0 | 0.580 | 86.34 | 149.06 |
| 19 | 26072‡‡ | 4.1 | 1.5 | R | F | R | 5 | 1.311 | 1192 | H | 22.9 ± 2.0 | 20.3 ± 2.2 | 0.618 | 120.85 | 196.70 |
| 20 | AP02‡‡ | 5.6 | 18.6 | R | F | L | 9 | 1.368 | 1016 | H | 21.9 ± 3.1 | 20.4 ± 2.3 | 0.627 | 89.60 | 143.67 |
| 21 | AM76‡‡ | 8.6 | 21.9 | R | F | L | 10 | 1.570 | 800 | H | 23.1 ± 2.6 | 21.4 ± 2.4 | 0.638 | 116.02 | 182.50 |
| Overall mean, SD | 6.3 ± 1.7 | 8.9 ± 6.5 | 9.9 ± 2.1 | 1.261 ± 0.187 | 555 ± 319 | 19.1 ± 2.7 | 26.7 ± 4.2 | 0.443 ± 0.107 | 79.17 ± 26.88 | 179.88 ± 51.26 | |||||
| Summary | 16R/5C | 9F/11M | 11R/10L | 9L/12H | |||||||||||
*
Study eyes are ordered (left column, 1–21, from smallest [1] to largest [21]) by their CTVF value.
†
R, rhesus; C, cynomolgus.
‡
F, female; M, male.
§
R, right; L, left.
‖
Mean IOP of n = 3 to 5 baseline measurements under ketamine/xylazine anesthesia.
¶
BMO area as determined by the area of the BMO ellipse within the postmortem 3D histomorphometric reconstruction.
#
Number of serial stained block face section images within the 3D HMRN.
**
H, high; L, low. See Methods.
††
Values are global for all FoBMO sectors, subsectors, and three laminar layers considered together.
‡‡
Longitudinal SDOCT data sets of both the control and contralateral EG eye of this animal has been previously reported43 and will be compared to LMA in future reports.