Table 4.

Post hoc sequence analysis of mediators (cytokines and chemokines) in BAL fluid

Sequence(A): 1.Period: UPF – 2.Period: Filtered air
Mediators BAL [pg/ml]	UFP mean (allergen-saline)	Filtered air (FA) mean (allergen-saline)	Treatment effect (UFP-FA)	95%-confidence interval	p-value
IL-6	−3.0	55.0	−58.0	−102.8; −13.1	0.019
MCP-1	38.0	210.0	−171.9	−303.3; −40.6	0.019
TNF-α	0.2	2.1	−1.9	−2.8; −1.0	0.002
Eotaxin	2.3	10.7	−8.4	−18.9; 2.1	0.097
IL10	0.9	7.2	−6.4	−14.3; 1.6	0.099
CD40L	2.4	2.3	0.2	−5.8; 6.1	0.948
GM-CSF	5.5	6.1	−0.6	−5.5; 4.3	0.779
IFN-γ	−0.5	0.1	−0.6	−2.5; 1.4	0.527
IL-13	8.8	67.1	−58.3	−137.5; 20.9	0.122
IL-17	0.1	0.3	−0.2	−0.8; 0.4	0.477
IL-2	1.1	1.00	0.1	−3.0; 3.2	0.928
IL-4	1.3	13.0	−11.8	−30.9; 7.4	0.184
IL-5	128.6	73.3	55.4	−313.1; 423.8	0.726
IL-7	−2.0	−0.4	−1.6	−19.0; 15.7	0.827
IL-8	20.9	48.0	−27.1	−96.1; 42.0	0.375
IL-1β	−0.1	1.0	−1.1	−2.9; 0.7	0.174
IL12p70	−0.3	0.01	−0.3	−1.0; 0.4	0.356
Sequence(B): 1.Period: Filtered air – 2.Period: UFP
Mediators BAL [pg/ml]	Filtered air (FA) mean (allergen-saline)	UFP mean (allergen-saline)	Treatment effect (UFP-FA)	95%-confidence interval	p-value
IL-6	12.3	30.5	18.2	−19.4; 55.9	0.250
MCP-1	27.4	113.5	86.1	−98.7; 270.9	0.265
TNF-α	0.2	1.3	1.1	−1.4; 3.5	0.289
Eotaxin	0.6	5.7	5. 2	−4.6; 14.9	0.216
IL10	0.9	8.5	7.7	−5.4; 20.8	0.179
CD40L	0.0	0.1	0.1	−0.2; 0.5	0.374
GM-CSF	2.4	2.5	0.1	−1.7; 1.9	0.910
IFN-γ	−0.3	0.4	0.6	−0.5; 1.7	0.181
IL-13	3.0	63.5	60.4	−46.7; 167.6	0.192
IL-17	0.0	1.2	1.2	−1.1; 3.4	0.237
IL-2	1.1	4.3	3.1	−9.9; 16.2	0.540
IL-4	0.0	7.8	7.8	−5.5; 21.0	0.178
IL-5	29.0	75.2	46.2	−39.1; 131.4	0.208
IL-7	−1.0	−0.8	0.3	−7.2; 7.8	0.928
IL-8	13.1	21.5	8.4	−28.9; 45.8	0.565
IL-1β	−0.1	0.1	0.1	−0.2; 0.5	0.374
IL12p70	−0.5	−0.6	−0.1	−1.1; 0.9	0.803