Table 2. Experimentally established involvement of the miRNAs from MDD × GAL and MDD × RL signatures in cellular processes (on the basis of PubMed search).

Physiological process	miRNA_ID
MDD × GAL miRNA
Metabolism	miR-33a*, miR-7, miR-296-5p, miR-181a*, miR-497*
Fatty acid metabolism	miR-296-5p, miR-193a-3p ×
P53	miR-1208, miR-1285, miR-7
Apoptosis/proliferation	miR-548c-5p, miR-7, miR-382, miR-296-5p, miR-181*, miR-193a-3p, miR-1285, miR-32, miR-497*
Migration/c-MET	miR-548c-5p, miR-7, miR-296-5p, miR-497*
Neurons/psychiatry	miR-7, miR-382, miR-296-5p, miR-32, miR-497*
MDD × RL miRNA
Metabolism	miR-33a, miR-7, miR-661, miR-1307, miR-376a, miR-26a, miR-132, miR-25, miR-98, miR-34a, miR-23a, miR-199a/b-3p, miR-296-5p
Fatty acid metabolism	miR-3613-3p, miR-33a, miR-192, miR-26a, miR-34a, miR-370, miR-15b, miR-296-5p
P53	miR-34b, miR-16-1*, miR-661, miR-192, miR-7, miR-134, miR-25, miR-98, miR-34a, miR-370, miR-15b, miR-199a/b-3p
Apoptosis/proliferation	miR-33a, miR-34b, miR-16-1*, miR-661, miR-192, miR-7, miR-376a, miR-382, miR-26a, miR-134, miR-379, let-7g, miR-132, miR-25, miR-98, miR-34a, miR-370, miR-15b, miR-23a, miR-199a/b-3p, miR-100, miR-296-5p
Migration/c-MET	miR-34b, miR-661, miR-550a, miR-7, miR-376a, miR-26a, let-7g, miR-134, miR-132, miR-25,miR-98, miR-34a, miR-100, miR-296-5p
Neurons/psychiatry	miR-34b, miR-7, miR-376a, miR-382, miR-26a, miR-134, miR-564, let-7g, miR-132, miR-25, miR-98, miR-34a, miR-370, miR-15b, miR-23a, miR-199a/b-3p, miR-296-5p

Abbreviations: GAL, galactose; MDD, major depressive disorder; miRNA, microRNA; RL, reduced lipid.

Metabolism/fatty acid metabolism.^{36, 63, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94} Apoptosis/proliferation/p53.^{37, 49, 54, 56, 58, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118}Migration.^{29, 54, 98, 99, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131} Neurons/psychiatry.^{48, 49, 50, 51, 53, 54, 56, 57, 58, 60, 61, 63, 64, 65, 66, 68, 69, 70, 71, 98, 132, 133, 134}