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. 2015 Mar 3;5(3):e517. doi: 10.1038/tp.2015.16

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effect of ASO on CORT-induced behaviors 28 days post implant. (a–c) Primary administration of ODN; (d–f) crossover study with opposite ODN treatment. (a and d) Experimental design for the respective studies. Experimental day is listed in each circle. Filled circles represent ODN dosing. (b) Following depletion of the CORT micropellet, the significantly decreased somatic withdrawal threshold in the CORT+RSO group was inhibited in CORT-implanted rats treated with ASO. (c) Visceral hypersensitivity to colonic distension that persisted in the CORT+RSO group was significantly decreased with ASO administration in the CORT-implanted group. (e) Somatic withdrawal threshold was dependent type of ODN administered in rats that had previously been implanted with CORT on the CeA. (f) Persistent visceral hyperalgesia in CORT+RSO-treated rats was significantly decreased with ASO treatment. Data shown are mean±s.d. ^*P<0.01, ^**P<0.01, ^***P<0.001 compared with CHOL+RSO, ^†P<0.05, ^†††P<0.001 compared with CORT+RSO, two- or three-factor analysis of variance with or without repeated measures, Tukey–Kramer post hoc analysis. ASO, antisense oligodeoxynucleotide; CeA, central amygdala; CORT, corticosterone; ODN, oligodeoxynucleotide; RSO, random sense oligodeoxynucleotide.