Table 2. Spearman rank correlations (rho) of changes in depression and anxiety symptoms with changes in regional glucose metabolism.

	Apparent sadness	Reported sadness	Concentration difficulties	Lassitude	Depressed mood	Work and activities	Feeling hot	Heart pounding/racing	Feeling of choking	Hands trembling
DLPFC, left	0.17	0.07	0.03	−0.50	0.57*	−0.55*	0.02	−0.05	0.18	−0.37
DLPFC, right	−0.66**	−0.57*	−0.34	−0.09	−0.63*	−0.44	0.22	−0.11	−0.14	−0.30
Anterior PFC, left	0.79***	0.73**	0.71**	0.24	0.45	0.36	−0.46	−0.28	−0.50	−0.02
Anterior PFC, right	−0.06	−0.14	0.17	−0.02	0.02	−0.23	0.63*	−0.05	−0.23	−0.14
Hippocampus, left	−0.20	−0.19	−0.03	0.05	−0.07	−0.15	0.63*	−0.22	−0.27	−0.24
Hippocampus, right	0.50	0.46	0.70**	0.09	0.63*	0.09	−0.09	−0.27	−0.18	−0.11
Ventral striatum, left	0.53*	0.55*	0.19	−0.65**	0.58*	−0.19	0.03	0.09	0.05	−0.27
Ventral striatum, right	−0.31	−0.16	−0.41	−0.64*	−0.12	−0.09	0.25	−0.13	0.00	−0.32
Pregenual PFC, right	−0.34	−0.31	−0.12	−0.12	−0.31	0.00	−0.17	−0.53*	−0.41	−0.35
PCC, left	−0.37	−0.32	−0.42	−0.16	−0.32	0.08	0.29	0.49	0.14	0.55*
PCC, right	0.39	0.42	0.30	0.33	0.05	0.59*	−0.38	−0.13	−0.18	0.10
Anteromedial PFC, left	−0.02	−0.09	0.09	−0.01	0.07	−0.13	−0.27	0.49	0.54*	0.39
Anterior insula, left	0.28	0.23	−0.01	−0.22	0.59*	0.03	−0.01	0.20	0.23	0.10

Abbreviations: CD, catecholamine depletion; DLPFC, dorsolateral prefrontal cortex; PCC, posterior cingulate cortex; PFC, prefrontal cortex; TD, tryptophan depletion.

Items were chosen according to our previous analyses, that is, where we had found significant differences between TD and CD. Note that there were no significant correlations of TD-induced changes in depression and anxiety symptoms with corresponding changes in regional glucose metabolism, so all values correspond to findings that were induced by CD. Statistically significant correlations are indicated in bold. Significance at *P<0.05; significance at **P<0.01; significance at ***P<0.001.