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. 2015 Mar 17;5(3):e532. doi: 10.1038/tp.2015.25

Table 3. Summary of the main findings of the study, categorized by common and differential effects. Effects on behavior relate to subjects with remitted depression only.

  Common effects Differential effects
    TD>CD CD>TD
Behavior Global HAMD Global MADRS Global BAI Depressed mood Sadness Work and activities Concentration difficulties Lassitude
Cerebral glucose metabolism Whole brain Ventral striatum Medial thalamus, right OFC, left Pregenual PFC, right Ventrolateral PFC, left PCC, right OFC Anterior PFC, left Subgenual PFC, right

Abbreviations: BAI, Beck Anxiety Inventory; CD, catecholamine depletion; HAMD, Hamilton Depression Scale; MADRS, Montgomery–Åsberg Depression Rating Scale; OFC, orbitofrontal cortex; PCC, posterior cingulate cortex; PFC, prefrontal cortex; TD, tryptophan depletion.