Table 3. Summary of the main findings of the study, categorized by common and differential effects. Effects on behavior relate to subjects with remitted depression only.
Common effects | Differential effects | ||
---|---|---|---|
TD>CD | CD>TD | ||
Behavior | Global HAMD Global MADRS Global BAI | Depressed mood Sadness | Work and activities Concentration difficulties Lassitude |
Cerebral glucose metabolism | Whole brain Ventral striatum Medial thalamus, right OFC, left | Pregenual PFC, right Ventrolateral PFC, left PCC, right OFC | Anterior PFC, left Subgenual PFC, right |
Abbreviations: BAI, Beck Anxiety Inventory; CD, catecholamine depletion; HAMD, Hamilton Depression Scale; MADRS, Montgomery–Åsberg Depression Rating Scale; OFC, orbitofrontal cortex; PCC, posterior cingulate cortex; PFC, prefrontal cortex; TD, tryptophan depletion.