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. 2015 Mar 9;212(3):369–383. doi: 10.1084/jem.20140474

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© 2015 Allam et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Increased tumorigenesis in Naip1-6^Δ/Δ mice in AOM-induced CRC. Naip1-6^fl/fl (n = 9) and Naip1-6^Δ/Δ (n = 7) mice were injected with AOM (10 mg/kg) once per week for 6 wk and were analyzed at week 24. (A) Colonoscopy score assessed at week 24, (B) tumor burden (data are shown as mean ± SEM), and (C) tumor size assessed at 25 wk, expressed as percentage of tumors in the indicated size range, calculated on the entire cohort. In all panels, data are representative of two independent experiments. Data from male mice are shown (similar results were obtained in female mice). *, P < 0.05; ****, P < 0.0001.