TABLE 4.
The estimated effect of 1 year of age on % methylation per locus per group.
| Locus | Group | Effect | SE | P-value |
|---|---|---|---|---|
| H19 ICR | CON | –0.05 | 0.10 | 0.634 |
| H19 ICR | FAS | 0.02 | 0.06 | 0.749 |
| IG-DMR.A | CON | 0.02 | 0.10 | 0.861 |
| IG-DMR.A | FAS | –0.43 | 0.06 | <0.001 |
| IG-DMR.B | CON | 0.01 | 0.10 | 0.920 |
| IG-DMR.B | FAS | –0.38 | 0.06 | <0.001 |
| KvDMR1 | CON | 0.19 | 0.08 | 0.016 |
| KvDMR1 | FAS | –0.11 | 0.05 | 0.021 |
| PEG3 DMR | CON | –0.22 | 0.08 | 0.008 |
| PEG3 DMR | FAS | 0.00 | 0.05 | 0.948 |
CON, controls; FAS, FAS case; Effect, estimated percentage difference in methylation between patients of a specific age and those 1 year younger, in the specific group at the specific locus, using linear mixed-effects models, as described in methods section; SE, standard error of the effect. Significant: p < 0.05. Analysis is adjusted for sex (fixed), CpG sites, individuals and replicates (random effects).