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. 2015 Mar 3;9:1281–1292. doi: 10.2147/DDDT.S71557

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© 2015 Iman et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of girinimbine on angiogenesis markers.

Notes: Cells were lysed and protein arrays were performed. Cells were treated with 5 μg/mL girinimbine for 24 hours and whole cell protein was extracted. Equal amounts of protein (100 μg) from each sample were used for the assay. (A, B) Quantitative analysis in the arrays showed differences in the angiogenesis markers. (C) Representative images of the angiogenesis protein array (series 1) are shown for the control and (D) treatment. (E) The exact protein name of each dot in the array. (F) Representative images of the angiogenesis protein array (series 2) are shown for the control (G) and treatment. (H) The exact protein name of each dot in the array. Statistical significance is expressed as ***P<0.001; **P<0.01; *P<0.05 versus untreated control.

Abbreviations: EGF, epidermal growth factor; ENA, epithelial-derived neutrophil-activating peptide; GM-CSF, granulocyte macrophage-colony stimu lating factor; IFN, interferon; IL, interleukin; I-TAC, interferon-inducible T-cell alpha chemoattractant; MCP, monocyte chemoattractant protein; MMP, matrix metallopeptidase; NEG, negative; PDGF-BB, platelet-derived growth factor BB; PECAM-1, platelet endothelial cell adhesion molecule 1; PIGF, phosphatidylinositol-glycan biosynthesis class F; POS, positive; TGF, transforming growth factor; TIMP, tissue inhibitor of matrix metalloproteinases; TNF, tumor necrosis factor; uPAR, urokinase-type plasminogen activator receptor; VEGF-D, vascular endothelial growth factor D; VEGF-R2, vascular endothelial growth factor receptor 2; VEGF-R3, vascular endothelial growth factor receptor 3; RANTES, Regulated on Activation, Normal T Cell Expressed and Secreted; G-CSF, granulocyte colony stimulating factor; b FGF, basic fibroblast growth factor; b, basic.