Table 1.
Ligand specificity of PTHR family.
| Receptor | Species | Assay | Ligand specificity | Reference |
|---|---|---|---|---|
| PTH1R | Human | cAMP | hPTHrP ≈ hPTH ≈ zPTH1 ≈ zPTH2 > fPTHrP, no response to TIP39 | (14, 24) |
| PLC | hPTHrP ≈ hPTH | (19) | ||
| ERK1/2 | hPTHrP ≈ hPTH | (51) | ||
| IP1 | hPTHrP ≈ hPTH | (51) | ||
| Bindingc | hPTHrP ≈ hPTH | (52) | ||
| Mouse | cAMP | hPTHrP ≈ hPTH, no response to TIP39 | (50) | |
| Rat | cAMP | rPTHrP ≈ rPTH, no response to TIP39 | (16) | |
| Chicken | cAMP | cPTHrP ≈ hPTH > cPTH-L > cPTH | (17) | |
| PLC | cPTHrP, slight stimulation by cPTH-L and no response to and cPTH | (17) | ||
| Zebrafish | cAMP | hPTH ≈ hPTHrP ≈ fPTHrPA ≈ zPTH1 > zPTH2 | (18, 24) | |
| PLC | hPTHrP ≈ hPTH | (18) | ||
| Seabreama | cAMP | fPTH-L ≈ fPTHrPA > hPTH ≈ bPTH, low respond to hPTHrP, no response to fPTH, and fPTHrPb | (11) | |
| PLC | fPTHrPA ≈ hPTHrP ≈ hPTH ≈ fPTH-L ≈ fPTHA ≈ fPTHB, no response to fPTHrPB and bPTH | (11) | ||
| PTH2R | Human | cAMP | hTIP39 ≈ rTIP39 ≈ rPTH > hPTH | (53, 54) |
| PLC | hTIP39 ≈ rTIP39 > rPTH, no response to hPTH | (53) | ||
| Rat | cAMP | hTIP39 > rPTH | (16) | |
| Zebrafish | cAMP | hTIP39 ≈ zTIP39 > hPTH | (36) | |
| (SV) | cAMP | zTIP39 > hTIP39 | (36) | |
| PTH3R | Chicken | cAMP | cPTHr > cPTH, low response to cPTH-L | (17) |
| Zebrafish | cAMP | hPTHrP ≈ fPTHrPA ≈ zPTH1 > zPTH2 > hPTH | (18, 24) | |
| PLC | no response to hPTHrP and hPTH | (18) | ||
| Seabreamb | cAMP | fPTHrP, no response to hPTHrP and hPTH | (20) | |
| PLC | no response to fPTHrP | (20) |
aScale.
bEnterocyte.
cExtra-cellular domain.
SV, splice variant; h, human; r, rat; z, zebrafish; f, fugu; c, chicken; x, Xenopus.