Table 1.
Summary of mutant Nrg1/ErbB4 mouse models.
| Gene | Locomotion | PPI | Learning and memory | Gross anatomy | Interneuron | References |
|---|---|---|---|---|---|---|
| Nrg1+/- (TM) |
↑ | → | ND | ND | ND | Boucher et al., 2007 |
| ↑ | ↓ | ND | ND | ND | Stefansson et al., 2002 | |
| ↑ | ND | Y maze | Small ventricle | ND | O'Tuathaigh et al., 2007, 2010 | |
| Nrg1+/- (TM) |
→ | → | contextual FC ↓ cued FC ↓ |
ND | PV/Gad67 in HC ↓ (western blotting) |
Pei et al., 2014 |
| Nrg1+/- (TypeIII) |
→ | ↓ | T-Maze↓ | Enlarged lateral ventricle | ND | Chen et al., 2008 |
| Nrg1+/- | ↑ | → | ND | ND | ND | Duffy et al., 2008 |
| (EGF) | → | → | Contextual FC ↓ | ND | ND | Ehrlichman et al., 2009 |
| ErbB4+/- | ↑ | → | ND | ND | ND | Stefansson et al., 2002 |
| ErbB4f/- (Nestin-Cre) |
↓ | ND | Morri Water Maze ↑ (hetero) |
ND | ND | Golub et al., 2004 |
| ErbB4-/- (heart-rescued) |
↑ | ↓ | Contextual FC ↓ Cued FC ↓ |
ND | Number of PV neurons ↓ | Shamir et al., 2012 |
| ErbB4f/f (PV-Cre) |
↑ | ↓ | Contextual FC → Cued FC → |
ND | Number of PV neurons → | Shamir et al., 2012 |
| ErbB4f/f (PV-Cre) |
ND | ND | Contextual FC ↓ | ND | ND | Chen et al., 2010 |
| ErbB4f/f (Lhx6-Cre) |
↑ | ↓ | Y-maze ↓ | ND | Number of PV neurons → | Del Pino et al., 2013 |
OF, open field, PPI:prepulse inhibition; FC, fear conditioning; TM, transmembrane region; PV, parvalbumin; HC, hippocampus; ND, not determined.