Figure 1.

MMPs and smooth-muscle cell proliferation.

Notes: MMP-1, -2, -3, -8, and -9 have been shown to be involved in facilitating vascular remodeling by degrading the matrix separating the intima from the media and allowing smooth-muscle cell migration from the media to the intima. This smooth-muscle cell migration results in the occlusion of vessel walls and decreased blood flow to tissues in need of oxygen and nutrients carried by the blood.

Abbreviation: MMP, matrix metalloproteinase.