TABLE 2.
List of metabolites significantly associated with pulse-wave velocity after adjusting for age, BMI, experimental batch, family relatedness, and multiple testing
| Metabolite | Super-p | Sub-p | Beta (95% CI) | P |
| Methionine | a-a | Cysteine, methionine, SAM, taurine metabolism | −0.24 (−0.34; −0.15) | 1.33 × 10−6 |
| Glutamine | a-a | Glutamate metabolism | −0.22 (−0.32; −0.11) | 6.47 × 10−5 |
| Glycine | a-a | Glycine, serine and threonine metabolism | −0.23 (−0.33; −0.14) | 2.62 × 10−6 |
| Serine | a-a | Glycine, serine and threonine metabolism | −0.26 (−0.36; −0.16) | 1.86 × 10−7 |
| 3-Phenylpropionate (hydrocinnamate) | a-a | Phenylalanine and tyrosine metabolism | −0.18 (−0.27; −0.09) | 6.69 × 10−5 |
| Phenylacetylglutamine | a-a | Phenylalanine and tyrosine metabolism | −0.17 (−0.26; −0.08) | 1.37 × 10−4 |
| Indolepropionate | a-a | Tryptophan metabolism | −0.18 (−0.27; −0.09) | 1.64 × 10−4 |
| Trans-4-hydroxyproline | a-a | Urea cycle; arginine and proline metabolism | −0.19 (−0.28; −0.1) | 6.66 × 10−5 |
| Urea | a-a | Urea cycle; arginine and proline metabolism | −0.21 (−0.31; −0.11) | 8.47 × 10−5 |
| Glycerate | ch | Glycolysis, gluconeogenesis, pyruvate metabolism | −0.19 (−0.29; −0.09) | 1.28 × 10−4 |
| Threonate | c and v | Ascorbate and aldarate metabolism | −0.26 (−0.35; −0.16) | 1.17 × 10−7 |
| Uridine | n | Pyrimidine metabolism, uracil containing | −0.26 (−0.34; −0.17) | 9.03 × 10−9 |
a-a, amino-acid; c and v, cofactor and vitamin; ch, carbohydrate; CI, confidence interval; n, nucleotide; sub-p, sub pathway; super-p, super pathway.