Table 1.

Common genes downregulated, identified under two criteria: ≥ 1.5 ×^* and ≥ 2.0 ×^**

Gene	Symbol	1K/C	3K/C	Biological description
Alpha-2-glycoprotein 1, zinc*	Azgp1	−1.84	−2.43	Lipolysis, lung secretion
Calmin*	Clmn	−1.84	−2.0	Development, growth
Clusterin-like 1 (retinal)**	Clul1	−2.253	−3.34	Cell death cones: acts as a pro-death signal, inhibiting cell growth and survival
Coiled-coil domain-containing 40**	Ccdc40	−2.185	−3.15	Mitochondria transport: assembly of dynein regulatory complex (DRC) and inner  dynein arm complexes, which are responsible for ciliary beat regulation
FLT3-interacting zinc finger 1*	Fiz1	−1.83	−1.94	Tyrosine kinase, photoreceptors
Myosin binding protein H*	Mybph	−1.79	−1.69	Muscle activity
Paired-like homeodomain  transcription factor 2*	Pitx2	−1.77	−1.88	Heart development
Rhesus blood group-associated  A glycoprotein**	Rhag	−2.58	−3.87	Associated with rhesus blood group antigen expression; transport or channel function  in the erythrocyte membrane
S100 calcium binding protein A5**	eS100a5	−4.73	−3.87	Cell cycle differentiation exocytosis and endocytosis; stimulation of Ca2+-induced  Ca2+ release, and implicated in the transportation of proteins involved in mood  regulation, nociception and cell polarisation
T-box 2*	Tbx2	−1.87	−2.66	Group of transcription factors involved in limb and heart development
Transmembrane protein 138**	Tmem 138	−2.636	−3.95	Mutation leads to ciliary dysfunction and Joubert Syndrome (absence or  underdevelopment of the cerebellar vermis, an area of the brain that controls balance  and coordination)

1K/C, ratio of 1 × KA to control values; 3K/C, ratio of 3 × KA to control values.

^*Genes identified from a 1K/C ratio exceeding −1.5.

^**Genes identified from a 1K/C ratio exceeding −2.0.

Note that the negative signs indicate downregulation; −X/C for each experimental group. For example, −1.84 indicates 1.84× fold reduction in intensity values compared to control.