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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Hypertension. 2013 Aug 5;62(3):634–640. doi: 10.1161/HYPERTENSIONAHA.111.00160

Figure 4. Hypertension was not attributable to changes in cardiac function in SMC-Hif1α-KO mice.

Figure 4

(A) SMC-HIF-1α KO mice had cardiac hypertrophy leading to increased heart-to-body weight ratios vs. HIF-1α-WT. (B–D) Echocardiographic analysis in SMC-HIF-1α-KO and HIF-1α-WT mice showed a significant increase in IVS, without any effect on LVSd, LVDd, or in cardiac function measured as EF and FS. (E) Representative M-mode echocardiogram. Effect of dobutamine on first derivate of peak changes ventricular pressure (F) dP/dtmin, (G) dP/dTmax and (H) heart rate in SMC-HIF-1α-KO and control mice (n=10 per group).