Table 4. In vivo prediction of HDI from in vitro data.

Herbal Extracts	Inhibitor Concentration(μg/mL)	IC50 (μg/mL)	Ki =IC50/2	Inhibitory Potency I/Ki	Risk of HDI	Predicted % Inhibition $\frac{[I]\times 100}{[I]\times K_i}$
CYP1A2
T30	321.84	0.63	0.315	510	Likely	99.90
T41	1400	162	81	17	Likely	94.53
T66	1192.16	520.1	260.05	4.6	Likely	82.09
T60	1280	20	10	128	Likely	99.22
T80	1600	37	18.5	86.5	Likely	98.86
CYP2C9
T41	1400	383.3	191.65	7.3	Likely	87.96
T50	1200	174	87	13.8	Likely	93.24
CYP2C19
T66	1192.16	43.52	21.76	596.1	Likely	98.22
CYP2D6
T30	321.84	446	223	1.44	Likely	59.00
T41	1400	870.6	435.3	3.2	Likely	76.28
T79	131	198	99	1.3	Likely	56.96
CYP3A4
T30	321.84	58	29	11.0	Likely	91.49
T79	131	740	370	0.35	Possible	26.15
T60	1280	12	6	213	Likely	99.53
T80	1600	300	150	10.7	Likely	91.43