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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Cell Rep. 2015 Feb 26;10(8):1375–1385. doi: 10.1016/j.celrep.2015.02.003

Figure 2.

Figure 2

Fatty acid elongase 7 is strongly induced by HCMV and required for efficient production of infectious progeny.

(A) ELOVL1-7 mRNA levels during the course of HCMV replication. MRC-5 fibroblasts infected at 3 IU/cell were compared to mock infected cells for ELOVL1-6. The (*) denotes that, because the ELOVL7 transcript was not detectable in uninfected cells, the ELOVL7 the data is reported as fold change from 4 hpi.

(B) HCMV replication in MRC-5 fibroblasts with shRNA knockdown of ELOVL1-7 (compared to non-targeting (NT) sequence control). Knockdown cells were infected at 0.5 IU/cell and at 96 hpi the medium was assayed for infectious progeny. (* p<0.05, t-test)

All data are represented as mean ± SEM of at least three independent experiments. See also Figure S2.