Table 5.
Results of Proportional Hazards Model for WHI Prolapse Grade 2 or 3 in Whites, Blacks, and Hispanics
| Baseline Characteristic |
White N=11,185 |
Black N=800 |
Hispanic N=665 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR* | 95% CI | p-value | HR* | 95% CI | p-value | HR* | 95% CI | p-value | |
| Age | 1.01 | (1.00, 1.02) | 0.01 | 1.05 | (1.01, 1.09) | 0.03 | 1.05 | (1.01, 1.09) | 0.17 |
|
Parity (vs. Never had a term pregnancy) |
<.0001 | 0.008 | 0.004 | ||||||
| 1 | 2.50 | (1.68, 3.71) | 0.77 | (0.05, 12.40) | - | - | |||
| 2 | 3.31 | (2.36, 4.63) | 4.35 | (0.56, 33.97) | - | - | |||
| 3 | 3.75 | (2.69, 5.23) | 3.86 | (0.48, 30.77) | - | - | |||
| 4 | 4.86 | (3.48, 6.80) | 6.12 | (0.75, 50.21) | - | - | |||
| 5+ | 5.29 | (3.79, 7.38) | 10.41 | (1.38, 78.77) | - | - | |||
|
Smoking (vs. Never smoked) |
<.0001 | 0.06 | 0.33 | ||||||
| Past smoker | 0.74 | (0.66, 0.83) | 0.48 | (0.25, 0.92) | 1.33 | (0.79, 2.24) | |||
| Current smoker | 0.52 | (0.41, 0.66) | 0.48 | (0.16, 1.44) | 0.50 | (0.12, 2.15) | |||
|
Moderate/Severe constipation |
1.04 | (0.84, 1.29) | 0.70 | 0.99 | (0.38, 2.55) | 0.98 | 0.50 | (0.22, 1.11) | 0.09 |
| Asthma | 0.95 | (0.75, 1.20) | 0.68 | 2.16 | (0.91, 5.14) | 0.08 | 0.62 | (0.19, 2.06) | 0.43 |
| Emphysema | 1.18 | (0.86, 1.62) | 0.31 | 1.44 | (0.40, 5.13) | 0.58 | 1.27 | (0.29, 5.66) | 0.75 |
|
Total hormone usage (vs. Never used) |
0.33 | 0.06 | 0.77 | ||||||
| Past user | 1.06 | (0.93, 1.21) | 1.37 | (0.67, 2.82) | 1.23 | (0.68, 2.22) | |||
| Current user | 1.17 | (0.93, 1.46) | 3.33 | (1.22, 9.06) | 0.92 | (0.33, 2.59) | |||
| E+P Treatment (vs. Placebo) | 1.17 | (1.05, 1.30) | 0.005 | 1.02 | (0.58, 1.80) | 0.95 | 0.74 | (0.45, 1.20) | 0.22 |
| Incontinence (vs. Never) | 0.002 | 0.99 | 0.78 | ||||||
| Stress | 1.15 | (0.98, 1.34) | 0.91 | (0.39, 2.12) | 0.73 | (0.39, 1.36) | |||
| Urge | 1.36 | (1.17, 1.59) | 0.94 | (0.49, 1.82) | 1.07 | (0.56, 2.03) | |||
| Mixed | 1.27 | (1.06, 1.52) | 0.71 | (0.17, 3.09) | 0.96 | (0.41, 2.24) | |||
| Other | 1.09 | (0.82, 1.43) | - | - | 1.33 | (0.40, 4.48) | |||
|
Waist circumference > 88 cm |
1.24 | (1.06, 1.45) | 0.007 | 0.67 | (0.31, 1.44) | 0.30 | 1.02 | (0.48, 2.16) | 0.96 |
| Physical activity | 0.99 | (0.94, 1.03) | 0.53 | 1.01 | (0.80, 1.27) | 0.92 | 1.07 | (0.88, 1.31) | 0.50 |
|
BMI (vs. <25 kg/m2) |
0.01 | 0.29 | 0.3909 | ||||||
| 25-<30 kg/m2 | 1.25 | (1.08, 1.46) | 1.23 | (0.47, 3.24) | 1.13 | (0.53, 2.42) | |||
| ≥ 30 kg/m2 | 1.23 | (1.00, 1.50) | 2.12 | (0.73, 6.19) | 1.82 | (0.70, 4.73) | |||
*
multi-variable adjusted HR