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. 2015 Feb 1;13:39. doi: 10.1186/s12967-015-0387-2

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© Yang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic drawing showed a series of studies using caspase-3 siRNA. The caspase-3 siRNA was first used to protect porcine renal tubular epithelia cells against hydrogen peroxide-induced injury. The renoprotection of naked caspase-3 siRNA with the same sequences was further validated in a porcine ex vivo isolated reperfusion model, then shown that the siRNA was effective for cold preservation, but not in auto-transplanted kidneys without systematic siRNA treatment. Finally, the modified siRNA of caspase-3 via locked nucleic acid stabilized the siRNA in serum, and significantly protected auto-transplanted kidneys.