Table 1.
Substrate | kcata | KMa | kcat/KMa | Reference |
---|---|---|---|---|
(sec−1) | (μM) | (sec−1M−1) | ||
MMP-1 | ||||
Dnp-Pro-Gln-Gly~Ile-Ala-Gly-Trp | ND | ND | 230b | [Netzel-Arnett, 1991 #1307] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 827 | [Murphy, 1992 #130] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 830 | [Knight, 1992 #1292] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala~Nva-Trp-Met-Lys(Dnp)-NH2 (NFF-2) | 0.15 | 142 | 1,060 | [Nagase, 1994 #813] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | 0.011c | 7.1c | 1,500c | [Stack, 1989 #1290] |
Mca-Pro-Lys-Pro-Gln-Gln~Phe-Phe-Gly~Leu-Lys(Dnp)-Gly (NFF-1) | 0.04 | 16.6 | 2,510 | [Nagase, 1994 #813] |
Dnp-Pro-Leu-Ala~Tyr-Trp-Ala-Arg | 0.13b | 50b | 2,700b | [Netzel-Arnett, 1991 #1307] |
Dnp-Pro-Leu-Ala~Leu-Trp-Ala-Arg | 1.2b | 130b | 9,400b | [Netzel-Arnett, 1991 #1307] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 12,100d | [Knäuper, 1996 #1324] |
Mca-Pro-Cha-Gly~Nva-His-Ala-Dpa-NH2 | ND | ND | 14,700d | [Knäuper, 1996 #1324] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 14,800 | [Knight, 1992 #1292] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | 2.5d | 27.5d | 92,200d | [Neumann, 2004 #2671] |
Dabcyl-Gaba-Pro-Gln-Gly~Leu-Glu(Edans)-Ala-Lys-NH2 | ND | ND | 21,000 | [Beekman, 1996 #902] |
LY-Gly-Pro-Leu-Gly~Leu-Arg-Ala-Lys(Ctmr) | ND | 3.9 | ND | [Geoghegan, 1993 #1294] |
Dns-Pro-Leu-Ala~Leu-Trp-Ala-Arg-NH2 | 0.417h | 145h | 7,300h | [Holtz, 1999 #3301] |
Dns-Pro-Leu-Ala~Cys(Mob)-Trp-Ala-Arg-NH2 | 0.150h | 17 | 8,800h | [Holtz, 1999 #3301] |
Dnp-Pro-Cha-Gly~Cys(Me)-His-Ala-Lys(Nma)-NH2 | ND | ND | 30,000 | [Mohan, 2002 #2459] |
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 76,000 | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 28,000 | [Moss, 2007 #3292] |
fTHP-4; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | 0.06k | 15.2k | 3,900k | [Minond, 2006 #2761] |
MMP-1(Δ243–450) | ||||
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 653 | [Murphy, 1992 #130] |
fTHP-4; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | 0.02k | 13.3k | 1,500k | [Minond, 2006 #2761] |
MMP-1 (19 kDa) | ||||
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 3,350b | [Bickett, 1993 #1296] |
Dnp-Pro-Cha-Gly~Cys(Me)-His-Ala-Lys(Nma)-NH2 | ND | ND | 13,000b | [Bickett, 1993 #1296] |
MMP-1(1–242) + MMP-3(248–460) | ||||
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 511 | [Murphy, 1992 #130] |
MMP-2 | ||||
Dnp-Pro-Gln-Gly~Ile-Ala-Gly-Trp | ND | ND | 4,200b | [Netzel-Arnett, 1991 #1307] |
Dnp-Pro-Leu-Gly~Met-Trp-Ser-Arg | 0.069b | 7.8b | 8,900b | [Netzel-Arnett, 1991 #1307] |
Mca-Pro-Lys-Pro-Gln-Gln~Phe-Phe-Gly-Leu-Lys(Dnp)-Gly (NFF-1) | 1.07 | 100 | 10,800 | [Nagase, 1994 #813] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala~Nva-Trp-Met-Lys(Dnp)-NH2 (NFF-2) | 2.70 | 50 | 54,400 | [Nagase, 1994 #813] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 58,000d | [Knight, 1992 #1292] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | 0.32c | 2.6c | 122,000c | [Stack, 1989 #1290] |
Dabcyl-Gaba-Pro-Gln-Gly~Leu-Glu(Edans)-Ala-Lys-NH2 | ND | ND | 619,000 | [Beekman, 1996 #902] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 629,000d | [Knight, 1992 #1292] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 687,000d | [Neumann, 2004 #2671] |
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 29,000 | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 320,000 | [Moss, 2007 #3292] |
Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2 | ND | ND | 2,400 | [Moss, 2007 #3292] |
α1(V)436–447 fTHP; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Pro-Gly~Val-Val-Gly-Glu-Lys(Dnp)-Gly-Glu-Gln-(Gly-Pro-Hyp)5-NH2 | 0.062k | 4.4k | 14,000k | [Lauer-Fields, 2003 #2028] |
MMP-3 | ||||
Dnp-Pro-Gln-Gly~Ile-Ala-Gly-Trp | ND | ND | 61b | [Netzel-Arnett, 1991 #1307] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 2,200 | [Murphy, 1992 #130] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 2,200 | [Knight, 1992 #1292] |
Dnp-Pro-Tyr-Ala~Tyr-Trp-Met-Arg-NH2 | 0.24b | 100b | 2,400b | [Netzel-Arnett, 1991 #1307] |
Mca-Pro-Lys-Pro-Gln-Gln~Phe-Phe-Gly-Leu-Lys(Dnp)-Gly (NFF-1) | 0.53 | 50 | 10,900 | [Nagase, 1994 #813] |
Dnp-Arg-Pro-Lys-Pro-Leu-Ala~Phe-Trp-NH2 | ND | ND | 17,000d | [Niedzwiecki, 1992 #768] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 23,000 | [Knight, 1992 #1292] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 20,400d | [Neumann, 2004 #2671] |
Dabcyl-Gaba-Pro-Gln-Gly~Leu-Glu(Edans)-Ala-Lys-NH2 | ND | ND | 40,000 | [Beekman, 1996 #902] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala~Nva-Trp-Met-Lys(Dnp)-NH2 (NFF-2) | 3.95 | 66 | 59,400 | [Nagase, 1994 #813] |
Dnp-Arg-Pro-Lys-Pro-Leu-Ala~Nva-Trp-NH2 | ND | ND | 45,000d | [Niedzwiecki, 1992 #768] |
Mca-Arg-Pro-Lys-Pro-Val-Glu~Nva-Trp-Arg-Lys(Dnp)-NH2 (NFF-3) | 1.31d | 20d | 65,700d | [Nagase, 1994 #813] |
Mca-Arg-Pro-Lys-Pro-Val-Glu~Nva-Trp-Arg-Lys(Dnp)-NH2 (NFF-3) | 5.40 | 25 | 218,000 | [Nagase, 1994 #813] |
Mca-Arg-Pro-Lys-Pro-Val-Glu~Nva-Trp-Arg-Lys(Dnp)-NH2 (NFF-3) | 2.20e | 7.5e | 302,000e | [Nagase, 1994 #813] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 6,500d | [Park, 2000 #1692] |
Mca-Pro-Lys-Pro-Leu-Ala-Leu-Dpa-Ala-Arg-NH2 | ND | ND | 45,300d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | ND | ND | 20,700d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 | ND | ND | 80,200d | [Park, 2000 #1692] |
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 | ND | ND | 1,200d | [Park, 2000 #1692] |
Dnp-Pro-Cha-Gly~Cys(Me)-His-Ala-Lys(Nma)-NH2 | ND | ND | 500 | [Mohan, 2002 #2459] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 4,000 | [Moss, 2007 #3292] |
MMP-3(Δ248–460) | ||||
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 2,390 | [Murphy, 1992 #130] |
MMP-3(1–233) + MMP-1(229–450) | ||||
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 2,750 | [Murphy, 1992 #130] |
MMP-7 | ||||
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 11,700 | [Knight, 1992 #1292] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 13,000f | [Crabbe, 1992 #3294] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 169,000 | [Knight, 1992 #1292] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 295,000d | [Neumann, 2004 #2671] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 131,000d | [Park, 2000 #1692] |
Mca-Pro-Lys-Pro-Leu-Ala-Leu-Dpa-Ala-Arg-NH2 | ND | ND | 320,000d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | ND | ND | 28,300d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 | ND | ND | 5,620d | [Park, 2000 #1692] |
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 | ND | ND | 3,420d | [Park, 2000 #1692] |
Dns-Pro-Leu-Ala~Leu-Trp-Ala-Arg-NH2 | 3.5h | 114h | 23,000h | [Holtz, 1999 #3301] |
Dns-Pro-Leu-Ala~Cys(Mob)-Trp-Ala-Arg-NH2 | 0.090h | 20h | 5,000h | [Holtz, 1999 #3301] |
Dnp-Pro-Cha-Gly~Cys(Me)-His-Ala-Lys(Nma)-NH2 | ND | ND | 10,000i | [Mohan, 2002 #2459] |
MMP-8 | ||||
Dnp-Pro-Gln-Gly~Ile-Ala-Gly-Trp | 21.0b | 1100b | 19,000b | [Netzel-Arnett, 1991 #1307] |
Dnp-Pro-Leu-Ala~Leu-Trp-Ala-Arg | 9.4b | 50b | 190,000b | [Netzel-Arnett, 1991 #1307] |
Dnp-Pro-Leu-Ala~Tyr-Trp-Ala-Arg | 3.1b | 7.7b | 400,000b | [Netzel-Arnett, 1991 #1307] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 418,000d | [Neumann, 2004 #2671] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 140,000 | [Moss, 2007 #3292] |
fTHP-4; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | 0.035k | 7.6k | 4,500k | [Minond, 2006 #2761] |
C10-fTHP-4 | 0.089k | 14.4k | 6,200k | [Minond, 2006 #2761] |
C16-fTHP-4 | 0.016k | 9.95k | 1,600k | [Minond, 2006 #2761] |
fTHP-9; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.94k | 5.4k | 175,000k | [Minond, 2006 #2761] |
C10-fTHP-9 | 0.64k | 8.8k | 73,000k | [Minond, 2006 #2761] |
C16-fTHP-9 | 0.13k | 9.6k | 14,000k | [Minond, 2006 #2761] |
fTHP-10; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.035k | 8.15k | 4,300k | [Minond, 2006 #2761] |
fTHP-11; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.38k | 19.7k | 19,000k | [Minond, 2006 #2761] |
C10-fTHP-11 | 0.007k | 3.60k | 1,900k | [Minond, 2006 #2761] |
C16-fTHP-11 | 0.007k | 3.50k | 2,100k | [Minond, 2006 #2761] |
C6-fTHP-12; C6-(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Leu-Gly~Met-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.070k | 14.5k | 5,090k | [Minond, 2007 #2768] |
fTHP-13; Cn-(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Val-Asn~Phe-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.028k | 9.30k | 3,010k | [Minond, 2007 #2768] |
C6-fTHP-13 | 0.020k | 3.90k | 3,870k | [Minond, 2007 #2768] |
MMP-8 (Met80 or Leu81 N-terminus) | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 135,000e | [Knäuper, 1996 #1324] |
Mca-Pro-Cha-Gly~Nva-His-Ala-Dpa-NH2 | ND | ND | 166,000e | [Knäuper, 1996 #1324] |
MMP-8 (Phe79 N-terminus) | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 193,000d | [Knäuper, 1996 #1324] |
Mca-Pro-Cha-Gly~Nva-His-Ala-Dpa-NH2 | ND | ND | 252,000d | [Knäuper, 1996 #1324] |
MMP-9 | ||||
Dnp-Pro-Gln-Gly~Ile-Ala-Gly-Trp | ND | ND | 1,200b | [Netzel-Arnett, 1991 #1307] |
Mca-Arg-Pro-Lys-Pro-Val-Glu~Nva-Trp-Arg-Lys(Dnp)-NH2 (NFF-3) | 0.282 | 28 | 10,100 | [Nagase, 1994 #813] |
Dnp-Pro-Leu-Gly~Met-Trp-Ser-Arg | 0.069b | 5.2b | 13,000b | [Netzel-Arnett, 1991 #1307] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala~Nva-Trp-Met-Lys(Dnp)-NH2 (NFF-2) | 1.38 | 25 | 55,300 | [Nagase, 1994 #813] |
Dnp-Pro-Leu-Gly~Leu-Trp-Ala-D-Arg-NH2 | ND | ND | 69,400b | [Bickett, 1993 #1296] |
Dnp-Pro-Cha-Gly~Cys(Me)-His-Ala-Lys(Nma)-NH2 | ND | ND | 86,600b | [Bickett, 1993 #1296] |
Dnp-Pro-Cha-Gly~Cys(Me)-His-Ala-Lys(Nma)-NH2 | ND | ND | 300,000 | [Mohan, 2002 #2459] |
Dabcyl-Gaba-Pro-Gln-Gly~Leu-Glu(Edans)-Ala-Lys-NH2 | ND | ND | 206,000 | [Beekman, 1996 #902] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 169,000 | [Knight, 1992 #1292] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 623,000d | [Neumann, 2004 #2671] |
Abz-Gly-Pro-Leu-Gly~Leu-Tyr(NO2)-Ala-Arg-NH2 | ND | ND | 150,000 | [Buchardt, 1999 #1847] |
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 850,000 | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 220,000 | [Moss, 2007 #3292] |
α1(V)436–447 fTHP; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Pro-Gly~Val-Val-Gly-Glu-Lys(Dnp)-Gly-Glu-Gln-(Gly-Pro-Hyp)5-NH2 | 0.044k | 8.1k | 5,500k | [Lauer-Fields, 2003 #2028] |
MMP-11 | ||||
Dns-Pro-Leu-Ala~Leu-Trp-Ala-Arg-NH2 | 0.012h | 21h | 570h | [Holtz, 1999 #3301] |
Dns-Pro-Leu-Ala~Cys(Mob)-Trp-Ala-Arg-NH2 | 0.078h | 5.2h | 15,000h | [Holtz, 1999 #3301] |
MMP-12 | ||||
Dnp-Arg-Pro-Leu-Ala-Leu~Trp-Arg-Ser-NH2 | ND | ND | 18,000 | [Gronski, 1997 #3300] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 61,000d | [Park, 2000 #1692] |
Mca-Pro-Lys-Pro-Leu-Ala-Leu-Dpa-Ala-Arg-NH2 | ND | ND | 968,000d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | ND | ND | 243,000d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 | ND | ND | 83,300d | [Park, 2000 #1692] |
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 | ND | ND | 13,000d | [Park, 2000 #1692] |
α1(V)436–447 fTHP; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Pro-Gly~Val-Val-Gly-Glu-Lys(Dnp)-Gly-Glu-Gln-(Gly-Pro-Hyp)5-NH2 | 2.35k | 24.8k | 97,600k | [Bhaskaran, 2008 #3295] |
MMP-13 | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 757,000d | [Knäuper, 1996 #1324] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | 5.9d | 5.2d | 1,135,000d | [Neumann, 2004 #2671] |
Mca-Pro-Cha-Gly~Nva-His-Ala-Dpa-NH2 | ND | ND | 1,090,000d | [Knäuper, 1996 #1324] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 2,520d | [Park, 2000 #1692] |
Mca-Pro-Lys-Pro-Leu-Ala-Leu-Dpa-Ala-Arg-NH2 | ND | ND | 2,680d | [Park, 2000 #1692] |
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | ND | ND | 408d | [Park, 2000 #1692] |
Dabcyl-Gly-Pro-Leu-Gly-Met-Arg-Gly-Cys(fluorescein)-NH2 | ND | ND | 1,600,000d | [Rasmussen, 2004 #2700] |
Dabcyl-Gly-Pro-Leu-Gly-Phe-Arg-Val-Cys(fluorescein)-NH2 | ND | ND | 2,700,000d | [Rasmussen, 2004 #2700] |
Dabcyl-Gly-Pro-Ser-Gly-Ile-His-Val-Cys(fluorescein)-NH2 | ND | ND | 2,500,000d | [Rasmussen, 2004 #2700] |
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 2,100,000 | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 460,000 | [Moss, 2007 #3292] |
fTHP-4; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | 0.015k | 8.6k | 1,600k | [Minond, 2006 #2761] |
C10-fTHP-4 | 0.013k | 3.4k | 3,800k | [Minond, 2006 #2761] |
C16-fTHP-4 | 0.0020k | 1.4k | 1,300k | [Minond, 2006 #2761] |
fTHP-9; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.16k | 6.25k | 25,000k | [Minond, 2006 #2761] |
C10-fTHP-9 | 0.060k | 3.45k | 18,000k | [Minond, 2006 #2761] |
C16-fTHP-9 | 0.028k | 2.50k | 11,000k | [Minond, 2006 #2761] |
fTHP-10; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.58k | 30.1k | 19,000k | [Minond, 2006 #2761] |
C10-fTHP-10 | 0.31k | 17.4k | 18,000k | [Minond, 2006 #2761] |
fTHP-11; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.18k | 13.7k | 13,000k | [Minond, 2006 #2761] |
C10-fTHP-11 | 0.013k | 7.10k | 1,900k | [Minond, 2006 #2761] |
C16-fTHP-11 | 0.007k | 7.68k | 940k | [Minond, 2006 #2761] |
C6-fTHP-12; C6-(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Leu-Gly~Met-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.060k | 6.35k | 9,710k | [Minond, 2007 #2768] |
fTHP-13; Cn-(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Val-Asn~Phe-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.127k | 20.5k | 6,116k | [Minond, 2007 #2768] |
C6-fTHP-13 | 0.060k | 9.95k | 5,800k | [Minond, 2007 #2768] |
MMP-13(Δ249–451) | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 639,000d | [Knäuper, 1997 #1060] |
Mca-Pro-Cha-Gly~Nva-His-Ala-Dpa-NH2 | ND | ND | 1,000,000d | [Knäuper, 1997 #1060] |
MMP-14 catalytic domain | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 393,000d | [Neumann, 2004 #2671] |
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | 9.9 | 7.9 | 1,253,000d | [Neumann, 2004 #2671] |
Dns-Pro-Leu-Ala~Leu-Trp-Ala-Arg-NH2 | 0.67h | 27h | 25,000h | [Holtz, 1999 #3301] |
Dns-Pro-Leu-Ala~Cys(Mob)-Trp-Ala-Arg-NH2 | 5.6h | 8h | 700,000h | [Holtz, 1999 #3301] |
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 1,900 | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 73,000 | [Moss, 2007 #3292] |
MMP-14(Δ279–523) | ||||
fTHP-4; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | 1.37k | 23.1k | 59,000k | [Minond, 2006 #2761] |
C10-fTHP-4 | 0.0033k | 0.80k | 4,100k | [Minond, 2006 #2761] |
C16-fTHP-4 | 0.0021k | 1.80k | 1,200k | [Minond, 2006 #2761] |
fTHP-9; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 1.34k | 7.95k | 168,000k | [Minond, 2006 #2761] |
C10-fTHP-9 | 0.080k | 2.80k | 29,000k | [Minond, 2006 #2761] |
C16-fTHP-9 | 0.200k | 6.60k | 30,000k | [Minond, 2006 #2761] |
fTHP-10; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.25k | 10.2k | 25,000k | [Minond, 2006 #2761] |
C10-fTHP-10 | 0.091k | 4.40k | 20,000k | [Minond, 2006 #2761] |
fTHP-11; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 1.30k | 16.6k | 78,000k | [Minond, 2006 #2761] |
C10-fTHP-11 | 0.036k | 3.50k | 11,000k | [Minond, 2006 #2761] |
MMP-14(Δ319–523) | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 73,700d | [Hurst, 2004 #2356] |
fTHP-4; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | ND | ND | 51,200d | [Hurst, 2004 #2356] |
MMP-14 | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 14,600d | [Hurst, 2004 #2356] |
fTHP-4; Cn-(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly~Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2 | ND | ND | 21,800d | [Hurst, 2004 #2356] |
MMP-15(Δ268–628) | ||||
fTHP-11; (Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Orn-Gly~Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2l | 0.41k | 14.3k | 29,000k | [Minond, 2006 #2761] |
MMP-17 catalytic domain | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | 0.05d | 8d | 5,800d | [Wang, 1999 #3299] |
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 | 0.42d | 26d | 16,000d | [Wang, 1999 #3299] |
MMP-25 catalytic domain | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 38,000d | [English, 2001 #2760] |
Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2 | ND | ND | 83,000d | [English, 2001 #2760] |
MMP-26 | ||||
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 1,850d | [Park, 2000 #1692] |
Mca-Pro-Lys-Pro-Leu-Ala-Leu-Dpa-Ala-Arg-NH2 | ND | ND | 343d | [Park, 2000 #1692] |
Dnp-Pro-Leu-Gly~Met-Trp-Ser-Arg | ND | ND | 9,400d | [Park, 2002 #3298] |
Mca-Pro-Cha-Gly~Nva-His-Ala-Dpa-NH2 | ND | ND | 17,000d | [Park, 2002 #3298] |
Mca-Pro-Leu-Ala~Nva-Dpa-Ala-Arg-NH2 | ND | ND | 30,000d | [Park, 2002 #3298] |
Mca-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 22,000d | [Park, 2002 #3298] |
ADAM8 | ||||
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 2,600j | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 100,000j | [Moss, 2007 #3292] |
Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2 | ND | ND | 53,000j | [Moss, 2007 #3292] |
ADAM10 | ||||
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 56j | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 6,200j | [Moss, 2007 #3292] |
Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2 | ND | ND | 270j | [Moss, 2007 #3292] |
ADAM12 | ||||
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 3,000j | [Moss, 2007 #3292] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 280,000j | [Moss, 2007 #3292] |
Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2 | ND | ND | 40j | [Moss, 2007 #3292] |
ADAM17 (TACE) | ||||
Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2 | ND | ND | 778,400d | [Neumann, 2004 #2671] |
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Ala-Arg-NH2 | ND | ND | 363,800d | [Neumann, 2004 #2671] |
Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Ala-Arg-NH2 | ND | ND | 466,300d | [Neumann, 2004 #2671] |
Dabcyl-Leu-Ala-Gln-Ala-Homophe-Arg-Ser-Lys(Fam)-NH2 | ND | ND | 430,000j | [Moss, 2007 #3292] |
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 | ND | ND | 6,800j | [Moss, 2007 #3292] |
ADAMTS-4-1 | ||||
Fam-Ala-Glu~Leu-Gln-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-Tamra | 0.86g | 10.7g | 80,200g | [Wayne, 2007 #3068] |
Lys(6-Fam)-Asp-Val-Gln-Glu-Phe-Arg-Gly-Val-Thr-Ala-Val-Ile-Arg-Cys(Qsy-9)-Lys-Gly-Lys | 0.22 | 1.0 | 215,000 | [Hills, 2007 #3042] |
ADAMTS-4-2 | ||||
fTHPa | 0.0120d | 47.1d | 415d | [Lauer-Fields, 2007 #2649] |
fSSPa | 0.0720d | 279.0d | 258d | [Lauer-Fields, 2007 #2649] |
Fam-Ala-Glu~Leu-Gln-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-Tamra | 2.79g | 16.2g | 172,000g | [Wayne, 2007 #3068] |
Assays were performed at 37 °C, pH 7.5 except where noted. ND = not determined.
Assay performed at 23 °C.
Porcine, not human, MMP.
Assay performed at 25 °C.
Assay performed at pH 6.0.
Assay performed at pH 6.5.
Assay performed at 20 °C, pH 8.0.
Assay performed at 25 °C, pH 6.8.
Assay performed at 22 °C.
Assay performed at 25 °C, pH 8.0.
Assay performed at 30 °C.
Substitutions relative to fTHP-4 are indicated in bold.