Table V.

Number (%) of patients with abnormal laboratory studies.

Primary analysis (n=60)	Baseline (n=60)			At any follow-up visit (n=60)
Lab name	Celecoxib/Creatine	Minocyline/Creatine	p-value for χ2	Celecoxib/Creatine	Minocyline/Creatine	p-value for χ2
WBC	4 (13.3)	0 (0.0)	0.112a	6 (20.0)	4 (13.3)	0.488
Hematocrit	1 (3.3)	1 (3.3)	1.000a	5 (16.7)	3 (10.0)	0.706a
Platelets	1 (3.3)	0 (0.0)	1.000a	1 (3.3)	1 (3.3)	1.000a
BUN	0 (0.0)	0 (0.0)		7 (23.3)	4 (13.3)	0.317
Cr >35% change from baseline	NA	NA		9 (30.0)	7 (23.3)	0.559
Cr abnormal (based on gender-specific ranges)	0 (0.0)	0 (0.0)		5 (16.7)	8 (26.7)	0.347
AST	5 (16.7)	2 (6.7)	0.424a	12 (40.0)	10 (33.3)	0.592
ALT	2 (6.7)	1 (3.3)	1.000a	9 (30.0)	7 (23.3)	0.559
Alkaline phosphatase	0 (0.0)	1 (3.3)	1.000a	4 (13.3)	5 (16.7)	1.000a
Total bilirubin	2 (6.7)	1 (3.3)	1.000a	3 (10.0)	1 (3.3)	0.612a
Any laboratory test	11 (36.7)	5 (16.7)	0.080	25 (83.3)	24 (80.0)	0.739
Secondary analysis (n=86)	Baseline (n=86)			At any follow-up visit (n=85)
WBC	5 (10.6)	1 (2.6)	0.215a	8 (17.4)	5 (12.8)	0.560
Hematocrit	4 (8.5)	2 (5.1)	0.685a	8 (17.4)	5 (12.8)	0.560
Platelets	1 (2.1)	0 (0.0)	1.000a	2 (4.3)	1 (2.6)	1.000a
BUN	0 (0.0)	0 (0.0)		11 (23.9)	4 (10.3)	0.100
Cr >35% change from baseline	NA	NA		10 (21.7)	11 (28.2)	0.491
Cr abnormal (based on gender-specific ranges)	0 (0.0)	0 (0.0)		6 (13.0)	11 (28.2)	0.082
AST	7 (14.9)	3 (7.7)	0.337a	15 (32.6)	11 (28.2)	0.661
ALT	4 (8.5)	1 (2.6)	0.371a	14 (30.4)	10 (25.6)	0.625
Alkaline phosphatase	1 (2.1)	1 (2.6)	1.000a	4 (8.7)	6 (15.4)	0.502a
Total bilirubin	4 (8.5)	1 (2.6)	0.371a	5 (10.9)	1 (2.6)	0.212a
Any laboratory test	16 (34.0)	8 (20.5)	0.164	37 (78.7)	31 (79.5)	0.931

^aFisher’s exact test.

ALT: serum alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; Cr: serum creatinine; WBC: white blood cell count.