Table 1.
Circulating miRNAs in ageing
| Species | Source | Circulating miRNA |
Expression in old |
Study design (young vs old) |
Method | Reference | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Human | Serum | miR-151-3p | miR-151-5p | miR-181-3p | miR-181-5p | miR-1248 | Down | 30.6 y (n = 11) vs
64.4 y (n = 11) |
Next generation sequencing |
Noren Hooten et al., 2013 |
|
|
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| miR-21-3p | miR-21-5p | miR-3607-5p | miR-3607-3p | |||||||
|
| ||||||||||
| Human | Plasma | miR-15b | miR-16 | miR-301a | miR-17-5p | miR-18a | Down | 20 y (n = 3) vs
80 y (n = 3) |
MicroRNA Array | Olivieri et al., 2012 |
|
|
||||||||||
| miR-320 | miR-20a | miR-20b | miR-361-5p | miR-25 | ||||||
|
|
||||||||||
| miR-26a | miR-26b | miR-423-5p | miR-29-3p | miR-451 | ||||||
|
|
||||||||||
| miR-29c | miR-92a | miR-486-3p | miR-93 | miR-106a | ||||||
|
|
||||||||||
| miR-541 | miR-106b | miR-128 | miR-532-5p | miR-132 | ||||||
|
|
||||||||||
| miR-146b-5p | miR-576-3p | miR-140-5p | miR-142-3p | miR-625 | ||||||
|
|
||||||||||
| miR-145 | miR-148a | miR-652 | miR-155 | miR-185 | ||||||
|
|
||||||||||
| Let-7b | Let-7g | Let-7c | Let-7d | miR-191 | ||||||
|
|
||||||||||
| miR-192 | miR-193a-5p | miR-199a-3p | miR-222 | miR-224 | ||||||
|
|
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| miR-200d | miR-200c | miR-212 | miR-425 | miR-579 | ||||||
|
| ||||||||||
| Human | Plasma | miR-19b | miR-21 | miR-30c | miR-126 | miR-186 | Up | 20 y (n = 3) vs
80 y (n = 3) |
MicroRNA Array | Olivieri et al., 2012 |
|
|
||||||||||
| miR-328 | miR-331-3p | miR-335 | miR-339-3p | miR-376a | ||||||
|
|
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| miR-484 | miR-590-5p | |||||||||
|
| ||||||||||
| Rhesus monkey |
Serum | miR-151a-5p | miR-1248 | miR-181-5p | Down | 7.7 y (n = 10) | Real-time PCR | Noren Hooten et al., 2013 | ||
|
| ||||||||||
| Mouse | Plasma | miR-34a | Up | 2 m (n = 3) vs
25 m (n = 3) |
Real-time PCR | Li et al., 2011 | ||||
|
| ||||||||||
| Mouse | Serum | miR-376b-3p | miR-543-3p | miR-129-5p | miR-129-1-3p | miR-409-3p | Up Down after CR |
7 m (n = 3) vs
27 m (n = 3) |
Next generation sequencing |
Dhahbi et al., 2013 |
|
|
||||||||||
| miR-129-2-3p | miR-155-5p | miR-134-5p | miR-485-3p | miR-341-3p | ||||||
|
|
||||||||||
| miR-667-3p | miR-217-5p | miR-431-5p | miR-673-5p | miR-485-5p | ||||||
| miR-300-3p | miR-434-3p | miR-668-3p | miR-410-3p | miR-3096a-5p | ||||||
|
|
||||||||||
| miR-592-5p | miR-122-5p | miR-183-5p | miR-212-3p | miR-298-5p | ||||||
|
|
||||||||||
| miR-148a-5p | miR-342-3p | miR-802-5p | miR-10a-5p | miR-99b-5p | ||||||
|
|
||||||||||
| miR-182-5p | miR-146a-5p | miR-10b-5p | miR-192-5p | miR-138-5p | ||||||
|
|
||||||||||
| miR-365-3p | miR-6240 | miR-5107-5p | miR-5128 | miR-1247-5p | ||||||
|
|
||||||||||
| miR-874-3p | miR-1943-5p | miR-5115 | miR-451a | miR-30096b-5p | ||||||
|
| ||||||||||
| Mouse | Serum | miR-144-3p | miR-16-2-3p | Down Up after CR |
7 m (n = 3) vs
27 m (n = 3) |
Next generation sequencing |
Dhahbi et al., 2013 | |||
CR, calorie restriction; y, year; m, month.