Skip to main content
. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: J Genet Genomics. 2014 Aug 6;41(9):465–472. doi: 10.1016/j.jgg.2014.07.003

Table 2.

Circulating miRNAs in ageing-related diseases

Species Source miRNA Disease Expression
in disease		 Study design
(non-disease vs disease)		 Method Reference
Human,
 rat		 Serum miR-1
 Acute myocardial
infarction (AMI)		 Up Human: n = 30 vs
n = 33;
Rat: n = 6 vs n = 6		 Real-time PCR Wang et al., 2010
miR-499
miR-208a
miR-133a
Rat Plasma miR-208 Myocardial injury Up n = 8 vs n = 8 Real-time PCR Ji et al., 2009
Human Microvesicles miR-150 Atherosclerosis Up n = 5 vs n = 5 Real-time PCR Zhang et al., 2010
Human Cerebrospinal
fluid (CSF),
extracellular
fluid (ECF)		 miR-9
 Alzheimer’s
disease (AD)		 Up n = 6 vs n = 6 MicroRNA Array Alexandrov et al., 2012
miR-146a
miR-155
Human Serum miR-125b
 Alzheimer’s
disease (AD)		 Down n = l50 vs n = 105 Real-time PCR Tan et al., 2014
miR-181c
miR-9 Up
Human Serum miR-137
 Alzheimer’s
disease (AD)		 Down n = 7 vs n = 7 Real-time PCR Geekiyanage et al., 2012
miR-181c
miR-9
miR-29a
miR-29b
Human Plasma miR-15a
 Type 2
diabetes mellitus
(T2DM)		 Down n = 80 vs n = 80 MicroRNA Array Zampetaki et al., 2010
miR-28-3p
miR-29b
miR-126
miR-223
Human Serum miR-9
 Type 2 diabetes
mellitus (T2DM)		 Up Newly diagnosed
T2DM patients:
n = 18;
Pre-diabetes
individuals: n = 19;
T2DM-susceptible
individuals: n = 19		 Real-time PCR Kong et al., 2011
miR-29a
miR-30d
miR-34a
miR-124a
miR-146a
miR-375
Human Exosomes miR-27a
 Type 2 diabetes
mellitus (T2DM)		 Up n = 46 vs n = 50 MicroRNA Microarray,
real-time PCR		 Karolina et al., 2012
miR-150
miR-192
miR-320a
miR-375