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. 2014 Sep 30;40(2):78–88. doi: 10.1503/jpn.130285

Fig. 2.

Fig. 2

Impaired working memory in medial prefrontal cortext (mPFC)-specific phospholipase C-β1 (PLC-β1) knockdown mice. Performance of mice injected with small hairpin scrambled sequence RNA (shSCR) and shPLC-β1 in a T-maze-based delayed non-match-to-sample (DNMTS) task using a delay of 4 seconds. (A) Days to reach the criterion for shPLC-β1-injected (n = 13) and shSCR-injected (n = 11) mice (p = 0.003, 2-tailed t-test). (B) Number of mice reaching the criterion within 10 d, as a percentage. (C) Cumulative distribution of the number of mice reaching the test criterion as a function of the number of test days, as a percentage (p = 0.12, 2-sample Kolmogorov–Smirnov test). (D) Correlation between the percentage of PLC-β1-positive neurons in the mPFC (x axis) and the number of days to reach the DNMTS T-maze task criterion for shPLC-β1-injected mice (y axis; shPLC-β1: n = 13; Pearson correlation test, R = −0.56; p = 0.047, 2-tailed t test). Data are presented as means ± standard errors of the mean. *p < 0.05, **p < 0.01, 2-tailed t test.