Fig. 4.
Normal sensorimotor gating in medial prefrontal cortex (mPFC)–specific phospholipase C-β1 (PLC-β1) knockdown mice. (A) Average startle amplitudes for various pulse types were not significantly different between small hairpin (sh)PLC-β1- and scrambled sequence (shSCR)–injected mice (shPLC-β1: n = 13, shSCR: n = 12; p > 0.05 for all pulse types, 2-tailed t test). (B) No significant difference in prepulse inhibition (PPI) percentage was observed between shSCR- and shPLC-β1-injected mice at 3 different prepulse intensities: 74, 82, 90 dB (shPLC-β1: n = 13, shSCR: n = 12; F1,23 = 0.306, p > 0.05 for all prepulse intensities). (C) The PPI values at all 3 prepulse intensities were lumped together and averaged. Data are presented as means ± standard errors of the mean. P = pulse; PP = prepulse.