Table 4.

Age-specific standardized incidence ratios (SIRs) for selected cancers among a cohort of female and male patients with rheumatoid arthritis, California, 1991–2002 (n = 84,475)

Cancer type	Females (n = 65,236)				Males (n = 19,239)
	Observed	Expected	SIR	95% CI	Observed	Expected	SIR	95% CI
Breast
<40	23	10.5	2.19	1.39–3.28
40–59	87	242.8	0.77	0.66–0.89
60–79	550	860.9	0.64	0.59–0.70
80+	82	229.2	0.36	0.28–0.45
Vagina/Vulva
<40	7	1.4	4.94	2.00–10.18
40–59	14	1 1.5	1.22	0.67–2.05
60–79	27	32.2	0.84	0.55–1.22
80+	8	11.5	0.70	0.30–1.37
Lung
<40	0	0.6	-	-	1	0.2	6.38	0. 16–35.5
40–59	122	46.6	2.62	2.17–3.12	50	21. 1	2.37	1.76–3.12
60–79	553	429.6	1.29	1.18–1.40	329	185.6	1.77	1.59–1.97
80+	87	116.8	0.75	0.60–0.92	36	45.5	0.79	0.55–1.10
Esophagus
<40	0	0	-	-	1	0	-	-
40–59	6	1.7	3.47	1.27–7.55	6	2.2	2.62	0.96–5.71
60–79	19	17.0	1.12	0.67–1.75	24	14.4	1.67	1.07–2.48
80+	2	6.6	0.30	0.03–1.10	5	3.6	1.40	0.45–3.27
Liver
<40	0	0.1	-	-	1	0.0	-	-
40–59	6	2.0	3.00	1.08–6.40	11	2.6	4.29	2.14–7.68
60–79	20	17.3	1.16	0.71–1.78	18	12.0	1.50	0.89–2.37
80+	10	6.1	1.65	0.79–3.03	2	2.7	0.73	0.09–2.65
NHL
<40	4	1.1	3.61	0.98–9.25	2	0.7	3.06	0.37–11.04
40–59	39	15.I	2.58	1.83 –3.52	20	8.2	2.44	1.49–3.76
60–79	141	96.2	1.47	1.23–1.73	92	36.5	2.52	2.03–3.09
80+	24	39.4	0.61	0.39–0.91	3	11.2	0.27	0.06–0.78
Hodgkin's Disease
<40	0	0.9	-	-	0	0.2	-	-
40–59	6	1.6	3.71	1.36–8.09	2	0.9	2. 17	0.26–7.87
60–79	9	5.3	1.7 1	0.78–3.24	7	2.0	3.49	1.40–7.19
80+	0	1.5	-	-	1	0.5	2.09	0.05–11.62
Leukemia
<40	0	0.6	-	-	0	-	-	-
40–59	19	7.5	2.53	1.57–3.88	6	3.9	1.54	0.62–3.20
60–79	67	51.1	1.31	1.01–1.67	51	26.9	1.90	1.43–2.47
80+	24	27.6	0.87	0.57–1.27	11	10.2	1.08	0.57– 1.87