Table 2.
Lead SNPs of the top loci associated with plasma renin activity (PRA) in the discovery cohorts. Replication with respect to circulating aldosterone levels and plasma renin concentration (PRC) in the PREVEND sample.
| Meta-analysis of the discovery samples (FHS Gen 3+SUVIMAX) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| SNP | Position | Trait | Chr | MAF | Coded allele | Direction | P-value | Gene | ||
| rs12374220 | 183677641 | PRA | 4 | 0.0651 | T | -- | 6.92×10-9 | TENM3 | ||
| rs5030062 | 187936874 | PRA | 3 | 0.3889 | A | -- | 8.57×10-9 | KNG1 | ||
| rs4253311 | 187411677 | PRA | 4 | 0.4828 | A | -- | 5.51×10-8 | KLKB1 | ||
|
| ||||||||||
| Replication sample (PREVEND) | ||||||||||
|
| ||||||||||
| SNP | Trait | N | Coded allele | Beta | P | Trait | N | Coded allele | Beta | P |
|
| ||||||||||
| rs12374220 | Aldosterone | 5,894 | T | -0.026 | 0.126 | PRC | 6325 | T | 0.0046 | 0.886 |
| rs5030062 | Aldosterone | 5,865 | A | 0.017 | 0.024 | PRC | 6296 | A | -0.046 | 0.001 |
| rs4253311 | Aldosterone | 5,875 | A | 0.028 | <0.001 | PRC | 6308 | A | -0.065 | <0.001 |
SNP, single nucleotide polymorphism; FHS, Framingham Heart Study; Gen 3, Third Generation cohort; SUVIMAX, Supplémentation en Vitamines et Minéraux Antioxydants; PREVEND, Prevention of REnal and Vascular ENd-stage Disease; KNG1, kininogen 1; KLKB1, kallikrein B; Chr, chromosome; MAF, minor allele frequency; TENM3, teneurin transmembrane protein 3