Table 3. Association of rs5030062 and rs4253311 with BP in the International Consortium for Blood Pressure Genome-Wide Association Studies;19 with renal traits in the CKDGen consortium;21 and with echocardiographically determined left ventricular mass in the EchoGen Consortium20.
rs5030062_A | rs4253311_A | |||||
---|---|---|---|---|---|---|
| ||||||
Study | Ethnicity | Trait | beta (SE) | p | beta (SE) | P |
ICBP19 | European descent | SBP | -0.165 (0.101) | 0.10 | 0.059 (0.097) | 0.54 |
ICBP19 | European descent | DBP | -0.077 (0.064) | 0.23 | 0.082 (0.061) | 0.18 |
EchoGen20 | European descent | LV mass | -0.662 (0.444) | 0.14 | -0.966 (0.440) | 0.03 |
CKDGen21 | European descent | eGFR | 0.0001 (0.001) | 0.96 | -0.002 (0.001) | 0.19 |
CKDGen21 | European descent | UACR | 0.013 (0.009) | 0.16 | -0.002 (0.009) | 0.80 |
CKDGen21 | European descent | CKD | -0.014 (0.022) | 0.53 | 0.023 (0.021) | 0.29 |
LV mass, left ventricular mass, echocardiographically determined; eGFR, estimated glomerular filtration rate, based on serum creatinine measurements; UACR, urinary albumin-to-creatinine ratio; CKD, chronic kidney disease; ICBP, International Consortium for Blood Pressure Genome-Wide Association Studies; SBP, systolic blood pressure; DBP, diastolic blood pressure