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. 2014 Sep 12;2(3):128–139. doi: 10.3390/microorganisms2030128

Table 1.

Antibiofilm activity and antibacterial activity of makaluvamine analogs against S. mutans.

graphic file with name microorganisms-02-00128-i001.jpg
Entry Compound No. R1 R2 Antibiofilm Activity IC50 (μM) a S. mutans MIC50 (μM) b
1 Ia graphic file with name microorganisms-02-00128-i002.jpg H 38.3 ± 3.6 32.6 ± 0.1
2 Ib graphic file with name microorganisms-02-00128-i003.jpg H 13.5 ± 0.8 23.1 ± 0.2
3 Ic graphic file with name microorganisms-02-00128-i004.jpg H 30.9 ± 4.6 34.2 ± 0.8
4 Id graphic file with name microorganisms-02-00128-i005.jpg H 84.7 ± 7.5 63.9 ± 13.6
5 Ie graphic file with name microorganisms-02-00128-i006.jpg H 22.4 ± 2.6 28.1 ± 0.4
6 If graphic file with name microorganisms-02-00128-i007.jpg H 13.9 ± 1.7 24.4 ± 0.2
7 Ig graphic file with name microorganisms-02-00128-i008.jpg H 30.4 ± 7.6 36.3 ± 0.8
8 Ih graphic file with name microorganisms-02-00128-i009.jpg H 70.1 ± 1.0 68.0 ± 4.1
9 Ii graphic file with name microorganisms-02-00128-i010.jpg H 88.2 ± 7.6 111.6 ± 27.4
10 IIa graphic file with name microorganisms-02-00128-i006.jpg graphic file with name microorganisms-02-00128-i011.jpg 16.3 ± 3.4 26.4 ± 0.6
11 IIb graphic file with name microorganisms-02-00128-i007.jpg graphic file with name microorganisms-02-00128-i011.jpg 2.5 ± 0.1 22.7 ± 0.6
12 IIc graphic file with name microorganisms-02-00128-i012.jpg graphic file with name microorganisms-02-00128-i011.jpg 2.6 ± 0.1 28.0 ± 1.9
13 IId graphic file with name microorganisms-02-00128-i013.jpg graphic file with name microorganisms-02-00128-i011.jpg 0.4 ± 0.1 1.7 ± 0.1
14 IIe graphic file with name microorganisms-02-00128-i009.jpg graphic file with name microorganisms-02-00128-i012.jpg 2.0 ± 0.1 5.8 ± 2.8
15 2A4 c graphic file with name microorganisms-02-00128-i014.jpg 0.94 ± 0.02 2.0 ± 0.5

a Determined by S. mutans biofilm inhibition assay; b determined by S. mutans growth inhibition assay; c reference biofilm inhibitor [34]; a,b measurements were carried out in triplicate, and the average value with standard deviation is reported.