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. 2015 Mar 10;10(3):e0120221. doi: 10.1371/journal.pone.0120221

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© 2015 Serratos et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — In the left panel, a schematic representation of the lesion site (dorsal striatum) in a drawing of a coronal section of the rat brain is depicted. Red line represents the needle trajectory. In the right panel, A-D micrographs (40X) show striatal sections stained with Haemotoxylin & Eosin (Bar size 100 μm), where A corresponds to Sham (mechanically lesioned right striatum); B is the contralateral (unlesioned) striatum in the same animal; C shows the right striatum lesioned by QUIN (240 nmol/μl); and D depicts the contralateral unlesioned striatum from the same QUIN-infused rat. Sham and unlesioned striata (A, B and D) show neuronal cells without structural alterations, whereas the QUIN-lesioned striatum (C) exhibits morphological alterations nearby the lesion site that were characterized by diffuse vacuolization, pyknosis, edema and neuropil degeneration.