Table 1. Absolute number (×10 4) of IL-12 and IL-6 producing dermal CD11c+ DCs and F4/80+ macrophages in C57BL/6 and BALB/c mice at 48 h post infection with L. major alone or in combination with 50 μg Pam3CSK4.
L. major | L. major+Pam3CSK4 | P values | ||
---|---|---|---|---|
C57BL/6 | ||||
CD11c + DCs | IL-12 | 7.3 ± 4.0 | 21.4 ± 3.9 | P = 0.005 |
IL-6 | 5.8 ± 2.6 | 15.7 ± 6.2 | P = 0.06 | |
F4/80 + Macrophages | IL-12 | 11.4 ± 1.2 | 32.3 ± 4.8 | P = 0.001 |
IL-6 | 5.7 ± 2.5 | 11.0 ± 1.2 | P = 0.03 | |
BALB/c | ||||
CD11c + DCs | IL-12 | 5.1 ± 1.3 | 11.3 ± 2.9 | P = 0.006 |
IL-6 | 4.5 ± 2.3 | 11.3 ± 2.7 | P = 0.02 | |
F4/80 + Macrophages | IL-12 | 4.4 ± 1.2 | 13.1 ± 3.3 | P = 0.01 |
IL-6 | 6.1 ± 3.0 | 18.8 ± 2.4 | P = 0.004 |
Data represent mean ± SD. n = 3 mice. Significant differences were determined by Student t test. P values obtained from comparing both groups are included in the table.