. Author manuscript; available in PMC: 2015 Mar 10.

Published in final edited form as: J Anal Bioanal Tech. 2014 Jan 24;5(1):180. doi: 10.4172/2155-9872.1000180

Table 3.

Kinetics of in-vitro release profile of STP and HI443 from SLNs.

Drug	Zero order release model		First order release model		Higuchi release model		Korsmeyer-Peppas model
	K₀^a	r²^b	K¹^a	r²^b	K_H^a	r²^b	k^a	n^c	r²^b
STP	0.21	0.52	0.027	0.83	6.63	0.46	0.21	0.11	0.65
HI443	0.28	0.75	0.030	0.94	6.68	0.90	0.07	0.26	0.97

Rate constant: K₀ in μg/min; K₁ in min⁻¹, K_H in μg/min^1/2, k in min⁻¹.

Square of the correlation coefficient.

Exponent explaining the drug release mechanisms and classified as Fickian diffusion (n ≤ 0.5), case-II transport (n=1), anomalous transport (0.5<n<1), and super case-II transport (n>1) [31].