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. 2014 Oct 21;211(7):1097–1103. doi: 10.1093/infdis/jiu565

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© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Q_i and Q_o site inhibitors are synergistic. ML238 was tested in combination with ATV (closed green squares and curve) and DEC (closed blue circles and curve) at multiple fixed volumetric ratios (10:0, 8:2, 6:4, 5:5, 4:6, 2:8, and 0:10) [16]. FICs for each drug were calculated and plotted. Synergy was defined as Σ FIC < 1, additivity as Σ FIC = 1, and antagonism as Σ FIC > 1. Abbreviations: ATV, atovaquone; DEC, decoquinate; FICs, fractional inhibitory concentrations; Q_o, ubiquinol oxidation center; Q_i, ubiquinone reduction site of cytochrome b.