Table 3.
Results of interaction tests between genetic factors and other putative risk factors for DTC
| rs944289 $ (near NKX2-1 ) | p-interaction | rs1801516 $ ( ATM ) | p- interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|
| C/C | C/T | T/T | G/G | G/A | A/A | ||||
| Ethnicity | |||||||||
| African | Cases/controls | 16/33 | 21/28 | 12/12 | 35/54 | 14/18 | 0/0 | ||
| OR (95% CI) | Ref | 1.5 (0.7–3.5) | 2.3 (0.8–6.3) | 0.9 | Ref | 1.2 (0.6–2.7) | |||
| Other | Cases/controls | 31/37 | 64/70 | 58/29 | 118/108 | 30/24 | 0/2 | 0.9 | |
| OR (95% CI) | Ref | 1.1 (0.6–2.0) | 2.4 (1.2–4.5) | Ref | 1.2 (0.7–2.2) | - | |||
| BMI (kg/m2) | |||||||||
| ≤ Median | Cases/controls | 27/40 | 33/53 | 19/22 | 68/90 | 21/21 | 0/2 | ||
| OR (95% CI) | Ref | 0.9 (0.4–1.8) | 2.1 (1.0–4.4) | 0.4 | Ref | 1.3 (0.6–2.4) | _ | 0.5 | |
| > Median | Cases/controls | 20/30 | 52/45 | 40/19 | 85/72 | 23/21 | 0/0 | ||
| OR (95% CI) | 1.7 (0.8–3.4) | 3.1 (1.4–6.8) | Ref | 1.0 (0.5–1.9) | - | ||||
| BSA (m2) | |||||||||
| ≤ Median | Cases/controls | 27/41 | 32/52 | 34/24 | 72/93 | 20/22 | 0/1 | ||
| OR (95% CI) | Ref | 1.0 (0.5–1.9) | 2.2 (1.0–4.4) | 0.5 | Ref | 1.2 (0.6–2.4) | _ | 0.9 | |
| > Median | Cases/controls | 20/29 | 53/46 | 36/17 | 81/69 | 24/20 | 0/1 | ||
| OR (95% CI) | Ref | 1.6 (0.6–3.3) | 3.1 (1.4–7.0) | Ref | 1.0 (0.5–2.0) | - | |||
| Size (m) | |||||||||
| ≤ Median | Cases/controls | 26/39 | 43/47 | 36/21 | 79/84 | 23/22 | 0/0 | ||
| OR (95% CI) | Ref | 1.3 (0.7–2.6) | 2.6 (1.2–5.4) | 0.9 | Ref | 1.2 (0.6–2.3) | - | ||
| > Median | Cases/controls | 21/31 | 42/51 | 34/20 | 74/78 | 21/20 | 0.2 | 0.8 | |
| OR (95% CI) | Ref | 1.3 (0.6–2.5) | 2.6 (1.2–57) | Ref | 1.0 (0.5–2.1) | - | |||
| Ever smoker | |||||||||
| No | Cases/controls | 33/46 | 56/56 | 54/22 | 107/98 | 32/22 | 0/2 | ||
| OR (95% CI) | Ref | 1.2 (0.5–2.7) | 1.4 (0.6–3.6) | Ref | 1.4 (0.8–2.7) | - | 0.2 | ||
| Yes | Cases/controls | 14/24 | 29/42 | 16/19 | 0.1 | 46/64 | 12/20 | 0 | |
| OR (95% CI) | Ref | 1.4 (0.8–2.5) | 3.5 (1.8–7.1) | Ref | 0.8 (0.3–0.7) | - | |||
| Pregnancy | |||||||||
| <2 | Cases/controls | 19/39 | 35/54 | 35/26 | 72/91 | 17/25 | 0/2 | ||
| OR (95% CI) | Ref | 1.3 (0.7–2.6) | 2.7 (1.2–5.7) | Ref | 0.8 (0.4–1.6) | - | |||
| ≥2 | Cases/controls | 24/21 | 38/22 | 27/9 | 0.9 | 61/46 | 23/5 | 0/0 | 0.03 |
| OR (95% CI) | Ref | 1.5 (0.7–3.4) | 2.6 (1.0–6.8) | Ref | 3.5 (1.2–9.8) | - | |||
All ORs and tests are stratified on sex and age.
$ Not including missing data.