Table 4.
Results of interaction tests between genetic factors and other putative risk factors for DTC
| rs965513 $ (near FOXE1 ) | P-interaction | rs1867277 $ (5′UTR of FOXE1 ) | p-interaction | rs71369530 $ (length polymorphism in FOXE1 ) | p-interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G/G | G/A | A/A | G/G | G/A | A/A | S/S* | L/S* | L/L* | |||||
| Ethnicity | |||||||||||||
| African | Cases/controls | 25/41 | 18/28 | 4/1 | 18/30 | 23/32 | 8/12 | 24/37 | 22/31 | 3/6 | |||
| OR (95% CI) | Ref | 1.1 (0.5–2.4) | 6.4 (0.7–0.4) | 0.3 | Ref | 1.2 (0.5–2.7) | 1.1 (0.4–3.1) | 0.4 | Ref | 1.1 (0.5–2.4) | 0.8 (0.2–3.3) | 0.09 | |
| Other | Cases/controls | 56/75 | 71/49 | 23/11 | 38/57 | 81/59 | 33/20 | 48/73 | 79/52 | 27/10 | |||
| OR (95% CI) | Ref | 2.0 (1.2–3.2) | 2.9 (1.3–6.4) | Ref | 2.0 (1.2–3.5) | 2.4 (1.2–4.9) | Ref | 1.1 (0.5–2.3) | 4.0 (1.8–3.2) | ||||
| BMI (kg/m2) | |||||||||||||
| ≤ Median | Cases/controls | 36/63 | 43/40 | 10/8 | 25/52 | 46/48 | 19/15 | 32/61 | 45/44 | 13/9 | |||
| OR (95% CI) | Ref | 1.9 (1.0–3.4) | 2.0 (0.7–5.6) | 0.3 | Ref | 2.0 (1.1–3.7) | 1.6 (1.1–6.0) | 0.6 | Ref | 1.9 (1.1–3.5) | 2.7 (1.1–6.9) | 0.9 | |
| > Median | Cases/controls | 45/53 | 46/37 | 17/4 | 31/35 | 58/43 | 22/17 | 40/49 | 56/39 | 17/7 | |||
| OR (95% CI) | Ref | 1.5 (0.8–2.8) | 5.7 (1.8–8.6) | Ref | 1.6 (0.8–3.0) | 1.4 (0.6–3.2) | Ref | 1.8 (1.0–3.2) | 2.9 (1.1–7.6) | ||||
| BSA (m2) | |||||||||||||
| ≤ Median | Cases/controls | 37/63 | 41/44 | 13/8 | 27/49 | 49/53 | 17/16 | 35/62 | 44/46 | 15/10 | |||
| OR (95% CI) | Ref | 1.6 (0.9–2.9) | 2.8 (1.1–7.5) | 0.8 | Ref | 1.6 (0.9–3.0) | 1.9 (0.8–4.4) | Ref | 1.7 (0.9–3.0) | 2.6 (1.1–6.5) | 0.9 | ||
| > Median | Cases/controls | 44/53 | 48/33 | 14/4 | 29/38 | 55/38 | 24/16 | 0.9 | 37/48 | 57/47 | 15/6 | ||
| OR (95% CI) | Ref | 1.8 (1.0–3.4) | 4.4 (1.3–14.6) | Ref | 2.0 (1.0–3.8) | 1.9 (0.9–4.3) | Ref | 2.1 (1.1–3.8) | 3.1 (1.1–8.7) | ||||
| Size (m) | |||||||||||||
| ≤ Median | Cases/controls | 42/59 | 42/41 | 16/6 | 28/48 | 58/44 | 20/16 | 35/55 | 55/42 | 16/11 | |||
| OR (95% CI) | Ref | 1.4 (0.8–2.7) | 3.8 (1.4–10.6) | 0.7 | Ref | 2.5 (1.4–4.7) | 2.3 (1.0–5.2) | 0.3 | Ref | 2.0 (1.1–3.6) | 2.2 (0.9–5.3) | 0.5 | |
| > Median | Cases/controls | 39/57 | 47/36 | 11/6 | 30/39 | 46/57 | 21/16 | 37/55 | 46/41 | 14/5 | |||
| OR (95% CI) | Ref | 2.0 (1.1–3.6) | 2.8 (0.9–8.3) | Ref | 1.3 (0.7–2.4) | 1.7 (0.8_3.8) | Ref | 1.7 (0.9–3.1) | 4.2 (1.4–12.5) | ||||
| Ever smoker | |||||||||||||
| No | Cases/controls | 57/70 | 60/46 | 22/6 | 43/55 | 71/54 | 28/16 | 55/68 | 68/49 | 21/6 | |||
| OR (95% CI) | Ref | 1.7 (1.0–2.8) | 4.8 (1.8–12.7) | Ref | 1.7 (1.0–2.9) | 2.1 (1.0–4.4) | 0.3 | Ref | 1.7 (1.0–2.8) | 4.2 (1.6–11.1) | 0.3 | ||
| Yes | Cases/controls | 24/46 | 29/31 | 5/6 | 0.3 | 13/32 | 33/37 | 13/16 | 17/42 | 33/34 | 9/10 | ||
| OR (95% CI) | Ref | 1.8 (0.9–3.7) | 1.4 (0.4–5.0) | Ref | 2.2 (1.0–4.9) | 1.9 (0.7–5.1) | Ref | 2.4 (1.1–5.0) | 2.1 (0.7–6.1) | ||||
| Pregnancies | |||||||||||||
| <2 | Cases/controls | 34/68 | 44/42 | 10/6 | 23/55 | 50/48 | 16/17 | 31/63 | 46/48 | 12/8 | |||
| OR (95% CI) | Ref | 2.0 (1.1–3.7) | 3.1 (1.0–9.2) | 0.8 | Ref | 2.5 (1.3–4.6) | 2.2 (0.9–5.0) | Ref | 2.0 (1.1–3.6) | 2.9 (1.1–7.9) | |||
| ≥2 | Cases/controls | 38/30 | 36/18 | 12/3 | 25/15 | 42/30 | 21/7 | 0.4 | 33/27 | 41/21 | 16/3 | 0.7 | |
| OR (95% CI) | Ref | 1.6 (0.8–3.2) | 3.1 (0.8–12.1) | Ref | 0.8 (0.4–1.8) | 1.7 (0.6–5.1) | Ref | 1.6 (0.8–3.3) | 4.3 (1.1–16.5) | ||||
All ORs and tests are stratified on sex and age.
*S for Short alleles (12–14 alanines) and L for Long allele (16–19 alanines).
$Not including missing data.