Skip to main content
. Author manuscript; available in PMC: 2015 Mar 11.
Published in final edited form as: Nat Rev Drug Discov. 2014 Oct 17;13(11):828–851. doi: 10.1038/nrd4389

Figure 1. Approaches to discover and develop pharmacologic inhibitors of mutant Ras.

Figure 1

Past and ongoing approaches to inhibitors of mutationally activated Ras include Ras-binding small molecules that disrupt a key function(s) of Ras, inhibition of the CAAX motif-targeted enzymes that promote Ras membrane association, inhibitors of effector signalling function, unbiased interfering RNA, genetic or chemical screens for synthetic lethal interactors and inhibitors of metabolism.