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. 2014 Dec 1;24(7):1869–1882. doi: 10.1093/hmg/ddu604

Figure 2.

Figure 2.

ET angles and morphology in Df1/+ mice and WT littermates. (A) 3D-reconstruction of the ET (grey) from the nasopharynx (arrow) to the middle ear cavity (arrowhead) and its associated cartilage (blue) of a 11.5-week-old WT mouse and (B) mutant Df1/+ littermate with OM showing no morphological differences. (C) Ventral view of a 3D-reconstructed microCT scan of a Df1/+ adult mutant skull with unilateral OM on the right hand side (asterisk), showing no obvious alterations of the ET angles (red lines) from the middle ear cavity orifice to the midline of the skull (dashed vertical line). (D and E) Measurements of ET angles from 3D-reconstructed skulls of animals between the ages of 3.5 and 18.5 weeks. (D) No significant difference in ET angles comparing Df1/+ mice (n = 16) with control littermates (n = 10) and (E) Df1/+ mice with clear middle ear cavities (n = 10) to Df1/+ mice with inflamed ears (n = 6). Statistical analysis was performed using Mann–Whitney test, P = 0.4546 and P = 0.5797, respectively.