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. 2014 Dec 1;24(7):1869–1882. doi: 10.1093/hmg/ddu604

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Neonatal Df1/+ and Tbx1^+/− mice have hypoplastic mLVP. (A and C) WT; (B) Df1/+; (D) Tbx1^+/−. The mLVP is outlined in white. (A and B) Immunohistochemistry against the skeletal muscle marker 12/101 stains the muscle fascicles of the mLVP in newborn control mice (A) and in Df1/+ littermates, showing a reduced muscle fascicle number. (D) A reduced muscle size can also be found in Masson's Trichrome-stained Tbx1^+/− mice compared with (C) control littermates. (E and F) Measurements of the mLVP show that muscle masses in neonatal Df1/+ (n = 4, E) and Tbx1^+/− (n = 6, F) animals are significantly smaller compared with their control littermates (WT = 4 and WT = 6, respectively; P = 0.0286 and 0.0022, respectively). (G) Scatter plot graph displaying the ratio of the two mLVP within each animal, demonstrating a significant size difference between these muscles in neonatal Tbx1^+/− mice (WT = 6, Tbx1^+/− = 6; P = 0.0411). Statistical analysis was performed using non-parametric Mann–Whitney test. Neonatal ages were ranging between E18.5 and P1. Note accumulated blood in the nasopharynx (NP; A, asterisk) occurred post-mortem. Scale bars: A and B, 100 µm; C and D, 200 µm.