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. 2014 Dec 1;24(7):1898–1907. doi: 10.1093/hmg/ddu606

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Figure 5. — Co-expression of Htt103Q-mCherry and α-syn-EGFP produces premature and severe degeneration in the photoreceptors. (A–D) External morphology of the adult eye. (A and B) Expression of GFP or α-syn-EGFP does not affect external eye morphology. (C and D) Co-expression of Htt103Q-mCherry and α-syn-EGFP produces a rough eye phenotype identical to the one induced by the single expression of Htt103Q-mCherry. (E–H) Photoreceptors neurodegeneration in the adult eye, analyzed by water immersion microscopy assay of the retinas. (E) Expression of GFP did not induce degeneration of the photoreceptors, with the six photoreceptors being present in the ommatidial clusters; (F, G) flies expressing α-syn-EGFP or Htt103Q-mCherry showed progressive degeneration of the photoreceptors. (H) Co-expression of Htt103Q-mCherry and α-syn-EGFP induced severe and early degeneration of the photoreceptors. Genotypes are indicated in the boxes on top and lateral of the figures: (A) sGMR-GAL4, UAS-GFP, (B) sGMR-GAL4, UAS-α-syn-EGFP, (C) sGMR-GAL4, UAS-Htt103Q-mCherry, (D) sGMR-GAL4, UAS-α-syn-EGFP/UAS-Htt103Q-mCherry, (E) Rh1-GAL4, UAS-GFP, (F) Rh1-GAL4, UAS-α-syn-EGFP, (G) Rh1-GAL4, UAS-Htt103Q-mCherry and (H) Rh1-GAL4, UAS-α-syn-EGFP/UAS-Htt103Q-mCherry. Scale bars represent 50 µm (A–D) and 10 µm (E–H).